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Volume 24, Number 10—October 2018
Research

Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase

Daisuke Hagiwara1, Teppei Arai1, Hiroki Takahashi, Yoko Kusuya, Akira WatanabeComments to Author , and Katsuhiko Kamei
Author affiliations: University of Tsukuba, Tsukuba, Japan (D. Hagiwara); Chiba University, Chiba City, Japan (D. Hagiwara, T. Arai, H. Takahashi, Y. Kusuya, A. Watanabe, K. Kamei)

Main Article

Table 2

Characteristics of Aspergillus fumigatus isolates from a single patient in Japan*

Isolate IFM no. Date isolated (isolate set) MCFG MEC, mg/L MIC, mg/L
Gene with mutation
AMPH ITCZ VRCZ PSCZ Cyp51 Hmg1 Erg6
60814
2001 Sep (1st)
<0.015
0.5
0.5
0.5
1




62916
2014 Sep (2nd)
<0.015
0.5
>8
>8
8

G448S
S269F
E49K
63240 2014 Nov (3rd) <0.015 1 >8 >8 4 S269F A350T
63241 <0.015 0.5 >8 >8 8 S269F A350T
63242 <0.015 1 >8 >8 8 S269F A350T
63243

<0.015
1
>8
>8
8


S269F
A350T
63248 Jan 2015 (4th) ND ND ND ND ND S269F E49K
63249

<0.015
1
4
8
8

G448S
S269F
E49K
63537
2015 Jul (5th)
<0.015
1
>8
8
8


S269F
A350T
63594 2015 Sep (6th) <0.015 1 >8 >8 8 S269F A350T
63595 <0.015 1 >8 >8 >8 G448S S269F E49K
63596

<0.015
1
>8
>8
8


S269F
A350T
63711 2015 Dec (7th) ND ND ND ND ND S269F E49K
63712 ND ND ND ND ND G448S S269F E49K
63713 ND ND ND ND ND G448S S269F E49K
63714

<0.015
1
>8
8
4


S269F
E49K
64138 2016 Apr (8th)
ND ND ND ND ND S269F E49K
64139
ND
ND
ND
ND
ND

G448S
S269F
E49K
64173 2016 May (9th) <0.015 0.5 >8 8 4 S269F A350T

*AMPH, amphotericin B; IFM, Institute of Food Microbiology (now Medical Mycology Research Center), Chiba University, Chiba City, Japan; ITCZ, itraconazole; MCFG, micafungin; MEC, minimal effective concentration; ND, not determined; PSCZ, posaconazole; VRCZ, voriconazole; –, no mutation.

Main Article

1These authors contributed equally to this article.

Page created: September 16, 2018
Page updated: September 16, 2018
Page reviewed: September 16, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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