Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 24, Number 10—October 2018
Research

Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase

Daisuke Hagiwara1, Teppei Arai1, Hiroki Takahashi, Yoko Kusuya, Akira WatanabeComments to Author , and Katsuhiko Kamei
Author affiliations: University of Tsukuba, Tsukuba, Japan (D. Hagiwara); Chiba University, Chiba City, Japan (D. Hagiwara, T. Arai, H. Takahashi, Y. Kusuya, A. Watanabe, K. Kamei)

Main Article

Table 4

Antifungal susceptibility test of mutants of erg6 and hmg1 from Aspergillus fumigatus isolates in Japan by transformation

Strain Genotype MCFG MEC, mg/L MIC, mg/L
AMPH ITCZ VRCZ MCZ PSCZ
1st+erg6WT cyp51A, erg6, +erg6WT, hmg1 <0.015 2 1 1–2 2 1–4
1st+erg6A350T cyp51A, erg6, +erg6A350T, hmg1 <0.015 2 1 0.5–1 2 4
1st+hmg1WT cyp51A, erg6, hmg1, +hmg1WT <0.015 2 1 1 2 1–4
1st+hmg1S269F cyp51A, erg6, hmg1, +hmg1S269F <0.015 1–2 0.5–1 0.5 1–2 2–4
1st+cyp51AWT cyp51A, +cyp51AWT, erg6, hmg1 <0.015 1–2 1 1–2 2–4 0.25–4
1st+cyp51AG448S cyp51A, +cyp51AG448S, erg6, hmg1 <0.015 1–2 4 >8 4 4

*AMPH, amphotericin B; ITCZ, itraconazole; MCFG, micafungin; MEC, minimal effective concentration; MCZ, miconazole; ND, not determined; PSCZ, posaconazole; STR, short tandem repeats; VRCZ, voriconazole.

Main Article

1These authors contributed equally to this article.

Page created: September 16, 2018
Page updated: September 16, 2018
Page reviewed: September 16, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external