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Volume 24, Number 11—November 2018
CME ACTIVITY - Synopsis

Rickettsia typhi as Cause of Fatal Encephalitic Typhus in Hospitalized Patients, Hamburg, Germany, 1940–1944

Jessica Rauch, Birgit Muntau, Petra Eggert, and Dennis TappeComments to Author 
Author affiliations: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

Main Article

Figure 2

Immunohistochemical analyses of nodule cell compositions from typhus patients during World War II, Hamburg, Germany, 1940–1944. Tissue sections were incubated with specific antibodies and visualized with immunoperoxidase (brown) or immunophosphatase (blue) stains and lightly counterstained with hematoxylin. A) CD3 stain (brown) for T cells and CD20 stain (blue) for B cells. Only T cells are visible within the nodule. Original magnification ×40. B, C) CD4 stain (brown) and CD8 stain (blue) for T

Figure 2. Immunohistochemical analyses of nodule cell compositions from typhus patients during World War II, Hamburg, Germany, 1940–1944. Tissue sections were incubated with specific antibodies and visualized with immunoperoxidase (brown) or immunophosphatase (blue) stains and lightly counterstained with hematoxylin. A) CD3 stain (brown) for T cells and CD20 stain (blue) for B cells. Only T cells are visible within the nodule. Original magnification ×40. B, C) CD4 stain (brown) and CD8 stain (blue) for T cell subsets. The nodules consist of a mixture of both cell types, with a predominance of CD8-positive cytotoxic T cells. Original magnifications ×40. D) CD68 stain (brown) for macrophages and microglia. A strong positivity is seen in the nodules and staining is also scattered in the surrounding brain parenchyma. Original magnification ×20.

Main Article

Page created: October 15, 2018
Page updated: October 15, 2018
Page reviewed: October 15, 2018
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