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Volume 24, Number 11—November 2018
Research

Effects of Pneumococcal Conjugate Vaccine on Genotypic Penicillin Resistance and Serotype Changes, Japan, 2010–2017

Kimiko UbukataComments to Author , Misako Takata, Miyuki Morozumi, Naoko Chiba, Takeaki Wajima, Shigeo Hanada, Michi Shouji, Megumi Sakuma, Satoshi Iwata, and the Invasive Pneumococcal Diseases Surveillance Study Group
Author affiliations: Keio University School of Medicine, Tokyo, Japan (K. Ubukata, M. Takata, M. Morozumi, N. Chiba, M. Sakuma, S. Iwata); Tokyo University of Pharmacy and Life Sciences, Tokyo (T. Wajima); Toranomon Hospital, Tokyo (S. Hanada); National Cancer Center Hospital, Tokyo (M. Shouji, S. Iwata)

Main Article

Table 1

Invasive pneumococcal disease in all patients, by age group, Japan, April 2010–March 2017

Disease
Total, no. (%), n = 2,856
Age, y, no. (%)
p value
<2, n = 731
3–5, n = 181
6–17, n = 94
18–49, n = 201
50–64, n = 387
65–74, n = 530
75–84, n = 457
>85, n = 275
Pneumonia with bacteremia* 1,198 (41.9) 130 (17.8) 35 (19.3) 22 (23.4) 83 (41.3) 167 (43.2) 261 (49.2) 300 (65.6) 200 (72.7) <0.001
Bacteremia with focus unknown 1,058 (37.0) 455 (62.2) 116 (64.1) 33 (35.1) 46 (22.9) 104 (26.9) 158 (29.8) 92 (20.1) 54 (19.6) <0.001
Meningitis 440 (15.4) 109 (14.9) 22 (12.2) 34 (36.2) 56 (27.9) 80 (20.7) 79 (14.9) 43 (9.4) 17 (6.2) <0.001
Other† 160 (5.6) 37 (5.1) 8 (4.4) 5 (5.3) 16 (8.0) 36 (9.3) 32 (6.0) 22 (4.8) 4(1.5) 0.002

*Includes empyema (n = 32) and pleuritis (n = 25).
†Includes endocarditis (n = 6), necrotizing fasciitis (n = 1), arthritis (n = 34), cellulitis (n = 20), and spondylitis (n = 7).

Main Article

Page created: October 17, 2018
Page updated: October 17, 2018
Page reviewed: October 17, 2018
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