TY - JOUR AU - Swanink, Caroline AU - Reimerink, Johan AU - Gisolf, Jet AU - de Vries, Ankje AU - Claassen, Mark AU - Martens, Liesbeth AU - Waegemaekers, Toos AU - Rozendaal, Harry AU - Valkenburgh, Stasja AU - Hoornweg, Tabitha AU - Maas, Miriam T1 - Autochthonous Human Case of Seoul Virus Infection, the Netherlands T2 - Emerging Infectious Disease journal PY - 2018 VL - 24 IS - 12 SP - 2158 SN - 1080-6059 AB - Orthohantaviruses are a group of rodentborne viruses with a worldwide distribution. The orthohantavirus Seoul virus (SEOV) can cause hemorrhagic fever with renal syndrome in humans and is distributed worldwide, like its reservoir host, the rat. Cases of SEOV in wild and pet rats have been described in several countries, and human cases have been reported in the United Kingdom, France, Canada, and the United States. In the Netherlands, SEOV has previously been found in wild brown rats. We describe an autochthonous human case of SEOV infection in the Netherlands. This patient had nonspecific clinical symptoms of an orthohantavirus infection (gastrointestinal symptoms and distinct elevation of liver enzymes). Subsequent source investigation revealed 2 potential sources, the patient’s feeder rats and a feeder rat farm. At both sources, a high prevalence of SEOV was found in the rats. The virus closely resembled the Cherwell and Turckheim SEOV strains that were previously found in Europe. KW - Seoul orthohantavirus KW - SEOV KW - hemorrhagic fever with renal syndrome KW - HFRS KW - rats KW - source investigation KW - zoonotic infection KW - viruses KW - the Netherlands KW - Seoul virus KW - orthohantavirus KW - zoonoses DO - 10.3201/eid2412.180229 UR - https://wwwnc.cdc.gov/eid/article/24/12/18-0229_article ER - End of Reference