Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 24, Number 12—December 2018
Research Letter

Lung Involvement in Chronic Schistosomiasis with Bladder Squamous Cell Carcinoma

Anastasia SaadeComments to Author , Edith Carton, Audrey Mansuet-Lupo, Romain Jouffroy, Diane Damotte, Hélène Yera, Marie-Pierre Revel, François Goldwasser, and YearGoldwasser
Author affiliations: Hopital Cochin, Paris, France (A. Saade, E. Carton, A. Mansuet-Lupo, D. Damotte, H. Yera, M.-P. Revel, F. Goldwasser); Universite Paris Descartes, Paris (A. Saade, R. Jouffroy, M.-P. Revel, F. Goldwasser)

Main Article

Figure

Schistosomiasis-induced squamous cell carcinoma of the bladder with pseudometastatic pulmonary nodules in a 30-year-old man from Mali. A) An unenhanced computed tomography axial image shows diffuse calcification of the wall bladder (arrow). A soft-tissue mass arises from the left posterolateral wall, breaching the calcifications and reaching the perivesical fat (asterisk). B) Anatomopathology slide stained with hematoxylin and eosin (original magnification ×10) of the bladder wall showing massiv

Figure. Schistosomiasis-induced squamous cell carcinoma of the bladder with pseudometastatic pulmonary nodules in a 30-year-old man from Mali. A) An unenhanced computed tomography axial image shows diffuse calcification of the bladder wall (arrow). A soft-tissue mass arises from the left posterolateral wall, breaching the calcifications and reaching the perivesical fat (asterisk). B) Anatomopathology slide stained with hematoxylin and eosin (original magnification ×10) of the bladder wall showing massive infiltration by a carcinomatous proliferation of the epidermoid type arranged in islands, or in broad cords in depth (arrows). The cells are large and polygonal, with eosinophilic cytoplasm. The papillomatous malpighian epithelium infiltrates the entire thickness of the chorion and the muscularis into the perivesical fat with venous vascular emboli (asterisk). Within the wall are observed bilharzia eggs, sometimes calcified (small arrow). The chorion is, on the other hand, the seat of a moderate mononuclear inflammatory infiltrate. C) Eggs of Schistosoma haematobium in a wet mount of urine concentrate, showing their characteristic terminal spine (original magnification ×400). D, E) Axial (D) and sagittal (E) reconstruction chest computed tomography of the lungs showing blurred ground glass nodules scattered over both lungs. F) A lung subpleural nodule of 0.2 cm greater axis shows at low magnification (original magnification ×4) a fibrous nodule surrounded by lymphoid follicles. G) Hematoxylin and eosin staining of the lung nodule (original magnification ×20) shows inflammatory population, mainly represented by eosinophils and a structure corresponding to a bilharzia egg. No territory suspected of malignancy was visualized.

Main Article

Page created: November 20, 2018
Page updated: November 20, 2018
Page reviewed: November 20, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external