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Volume 24, Number 12—December 2018
Research

Highly Pathogenic Clone of Shiga Toxin–Producing Escherichia coli O157:H7, England and Wales

Lisa Byrne1, Timothy J. Dallman1, Natalie Adams, Amy F.W. Mikhail, Noel McCarthy, and Claire JenkinsComments to Author 
Author affiliations: Public Health England, London, UK (L. Byrne, T.J. Dallman, N. Adams, A.F.W. Mikhail, C. Jenkins); National Institute for Health Research, London (T.J. Dallman, N. Adams, N. McCarthy); University of Warwick, Coventry, UK (N. McCarthy)

Main Article

Table 1

Clinical features of cases of Shiga toxin–producing Escherichia coli O157:H7 belonging to the IIb 250 SNP single linkage cluster 18.% by stx subtype clone, England and Wales, July 2015–December 2017

stx subtype No. patients Diarrhea
Bloody diarrhea†
Vomiting
Hospitalization‡
No. patients % Patients (95% CI) No. patients % Patients
(95% CI) No. patients % Patients
(95% CI) No. patients % Patients (95% CI)
stx2c 36 31 86.1 
(74.2–98.0) 7 22.6
(5.9–33.0) 10 32.3
(12.4–43.1) 3 8.3
(−1.1 to 17.8)
stx-negative 77 72 93.5
(87.8–99.1) 12 16.7
(7.3–23.9) 23 31.9
(19.4–40.3) 9 11.7
(4.3–19.0)
stx2a
138
127
92.0
(87.4–96.6)

69
54.3
(41.5–58.4)

38
29.9
(20.0–35.1)

35
25.4
(18.0–32.7)
Total 251 230 91.6
(88.1–95.1) 88 38.3
(29.1–41.0) 71 30.9
(22.7–33.9) 47 18.7
(13.9–23.5)

*SNP, single-nucleotide polymorphism.
†Statistically significant difference in reporting by stx subtype using Fisher exact test (p<0.001)
‡Statistically significant difference in reporting by stx subtype using Fisher exact test (p = 0.011)

Main Article

1These first authors contributed equally to this article.

Page created: November 20, 2018
Page updated: November 20, 2018
Page reviewed: November 20, 2018
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