TY - JOUR AU - Pirisinu, Laura AU - Tran, Linh AU - Chiappini, Barbara AU - Vanni, Ilaria AU - Di Bari, Michele AU - Vaccari, Gabriele AU - Vikøren, Turid AU - Madslien, Knut Ivar AU - Våge, Jørn AU - Spraker, Terry AU - Mitchell, Gordon AU - Balachandran, Aru AU - Baron, Thierry AU - Casalone, Cristina AU - Rolandsen, Christer AU - Røed, Knut AU - Agrimi, Umberto AU - Nonno, Romolo AU - Benestad, Sylvie T1 - Novel Type of Chronic Wasting Disease Detected in Moose (Alces alces), Norway T2 - Emerging Infectious Disease journal PY - 2018 VL - 24 IS - 12 SP - 2210 SN - 1080-6059 AB - Chronic wasting disease (CWD) persists in cervid populations of North America and in 2016 was detected for the first time in Europe in a wild reindeer in Norway. We report the detection of CWD in 3 moose (Alces alces) in Norway, identified through a large scale surveillance program. The cases occurred in 13–14-year-old female moose, and we detected an abnormal form of prion protein (PrPSc) in the brain but not in lymphoid tissues. Immunohistochemistry revealed that the moose shared the same neuropathologic phenotype, characterized by mostly intraneuronal deposition of PrPSc. This pattern differed from that observed in reindeer and has not been previously reported in CWD-infected cervids. Moreover, Western blot revealed a PrPSc type distinguishable from previous CWD cases and from known ruminant prion diseases in Europe, with the possible exception of sheep CH1641. These findings suggest that these cases in moose represent a novel type of CWD. KW - prion disease KW - transmissible spongiform encephalopathies KW - chronic wasting disease KW - cervid KW - moose KW - zoonoses KW - CWD KW - TSE KW - Alces alces KW - prions KW - transmissible spongiform encephalopathy KW - reindeer KW - Norway KW - Nor16CWD DO - 10.3201/eid2412.180702 UR - https://wwwnc.cdc.gov/eid/article/24/12/18-0702_article ER - End of Reference