Table 4

Use of Pristinamycin for Macrolide-Resistant Mycoplasma genitalium Infection

Tim R.H. Read

, Jørgen S. Jensen, Christopher K. Fairley, Mieken Grant, Jennifer A. Danielewski, Jenny Su, Gerald L. Murray, Eric P.F. Chow, Karen Worthington, Suzanne M. Garland, Sepehr N. Tabrizi, and Catriona S. Bradshaw

Author affiliations: Melbourne Sexual Health Centre, Alfred Health, Carlton, Victoria, Australia (T.R.H. Read, C.K. Fairley, M. Grant, E.P.F. Chow, K. Worthington, C.S. Bradshaw); Monash University, Melbourne, Victoria, Australia (T.R.H. Read, C.K. Fairley, G.L. Murray, E.P.F. Chow, C.S. Bradshaw); Statens Serum Institut, Copenhagen, Denmark (J.S. Jensen); Murdoch Children’s Research Institute, Parkville, Victoria, Australia (J.A. Danielewski, J. Su, G.L. Murray, S.M. Garland, S.N. Tabrizi); Royal Women’s Hospital, Parkville (J.A. Danielewski, J. Su, G.L. Murray, S.M. Garland, S.N. Tabrizi); University of Melbourne, Parkville (S.M. Garland, S.N. Tabrizi, C.S. Bradshaw)

Main Article

Proportions of Mycoplasma genitalium infections cured with and without silent mutations (no resulting amino acid change) in the L4 and L22 genes, Sexual Health Centre, Melbourne, Victoria, Australia, 2012–2016*

Mutation	No. cured/no. treated (%)†	Unadjusted odds ratio for cure (95% CI)	p value
L4 T327C
Absent	19/28 (68)
Present	2/5 (40)	0.32 (0.23–3.39)	0.23
L4 G429A
Absent	17/24 (71)
Present	4/9 (44)	0.33 (0.05–2.12)	0.16
L4 C438T ‡
Absent	18/25 (72)
Present	3/8 (38)	0.23 (0.030–1.65)	0.08
L4 C468T
Absent	17/27 (63)
Present	4/6 (67)	1.18 (0.14–15.2)	0.86
L4 G507A‡
Absent	18/25 (72)
Present	3/8 (38)	0.23 (0.030–1.65)	0.08
L4 C516T‡
Absent	18/25 (72)
Present	3/8 (38)	0.23 (0.030–1.65)	0.08
L22 G81A K27
Absent	18/26 (69)
Present	7/12 (58)	0.62 (0.12–3.34)	0.51
L22 C231T N77
Absent	17/24 (71)
Present	8/14 (57)	0.55 (0.11–2.73)	0.39
L22 C351T L117
Absent	23/34 (68)
Present	2/4 (50)	0.48 (0.032–7.56)	0.48

*M. genitalium numbering based on reference genome GenBank accession number L43967.2
†The L22 gene was sequenced in 38 infections and the L4 gene was sequenced in 33 infections.
‡These 3 mutations always occurred together.

Main Article

Page created: January 17, 2018

Page updated: January 17, 2018

Page reviewed: January 17, 2018

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