TY - JOUR AU - Carrim, Maimuna AU - Wolter, Nicole AU - Benitez, Alvaro AU - Tempia, Stefano AU - du Plessis, Mignon AU - Walaza, Sibongile AU - Moosa, Fahima AU - Diaz, Maureen AU - Wolff, Bernard AU - Treurnicht, Florette AU - Hellferscee, Orienka AU - Dawood, Halima AU - Variava, Ebrahim AU - Cohen, Cheryl AU - Winchell, Jonas AU - von Gottberg, Anne T1 - Epidemiology and Molecular Identification and Characterization of Mycoplasma pneumoniae, South Africa, 2012–2015 T2 - Emerging Infectious Disease journal PY - 2018 VL - 24 IS - 3 SP - 506 SN - 1080-6059 AB - During 2012–2015, we tested respiratory specimens from patients with severe respiratory illness (SRI), patients with influenza-like illness (ILI), and controls in South Africa by real-time PCR for Mycoplasma pneumoniae, followed by culture and molecular characterization of positive samples. M. pneumoniae prevalence was 1.6% among SRI patients, 0.7% among ILI patients, and 0.2% among controls (p<0.001). Age <5 years (adjusted odd ratio 7.1; 95% CI 1.7–28.7) and HIV infection (adjusted odds ratio 23.8; 95% CI 4.1–138.2) among M. pneumonia–positive persons were associated with severe disease. The detection rate attributable to illness was 93.9% (95% CI 74.4%–98.5%) in SRI patients and 80.7% (95% CI 16.7%–95.6%) in ILI patients. The hospitalization rate was 28 cases/100,000 population. We observed the macrolide-susceptible M. pneumoniae genotype in all cases and found P1 types 1, 2, and a type 2 variant with multilocus variable number tandem repeat types 3/6/6/2, 3/5/6/2, and 4/5/7/2. KW - Mycoplasma pneumoniae KW - community-acquired pneumonia KW - South Africa KW - severe respiratory illness KW - influenza-like illness KW - real-time PCR KW - macrolide susceptibility KW - molecular characterization KW - bacterial infection KW - bacteria KW - respiratory infections KW - antimicrobial resistance DO - 10.3201/eid2403.162052 UR - https://wwwnc.cdc.gov/eid/article/24/3/16-2052_article ER - End of Reference