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Volume 24, Number 3—March 2018
Research

Capsule Typing of Haemophilus influenzae by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry1

Viktor MånssonComments to Author , Janet R. Gilsdorf, Gunnar Kahlmeter, Mogens Kilian, J. Simon Kroll, Kristian Riesbeck2, and Fredrik Resman2
Author affiliations: Lund University, Malmö, Sweden (V. Månsson, K. Riesbeck, F. Resman); University of Michigan, Ann Arbor, Michigan, USA (J.R. Gilsdorf); Växjö Hospital, Växjö, Sweden (G. Kahlmeter); Aarhus University, Aarhus, Denmark (M. Kilian); Imperial College London, London, UK (J.S. Kroll)

Main Article

Figure 5

Principal component analysis of matrix-assisted laser desorption/ionization time-of-flight mass spectra of NTHi in the original and supplemented databases. Isolates are color-coded according to database affiliation, and the first 3 principal components (PC0, PC1, and PC2) are shown in 2-dimensional plots. No clustering similar to that for encapsulated isolates was observed. NTHi reference isolates in the original capsule typing database (n = 9), representing different genetic clades, were evenly

Figure 5. Principal component analysis of matrix-assisted laser desorption/ionization time-of-flight mass spectra of NTHi in the original and supplemented databases. Isolates are color-coded according to database affiliation, and the first 3 principal components (PC0, PC1, and PC2) are shown in 2-dimensional plots. No clustering similar to that for encapsulated isolates was observed. NTHi reference isolates in the original capsule typing database (n = 9), representing different genetic clades, were evenly distributed in the group. Supplementing the reference database with another 19 isolates improved coverage of the heterogeneity of NTHi. NTHi, nontypeable H. influenzae; PCA, principal component analysis.

Main Article

1Preliminary results from this study were presented at the IDWeek 2016 Conference, October 26−30, 2016, New Orleans, Louisiana, USA.

2These senior authors contributed equally to this article.

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