Volume 24, Number 3—March 2018
Dispatch
Drug Resistance of Mycobacterium tuberculosis Complex in a Rural Setting, Angola
Ariadna Rando-Segura1, María Luisa Aznar1, María Milagros Moreno, Mateu Espasa, Elena Sulleiro, Cristina Bocanegra, Eva Gil, Arlete N.E. Eugénio, Carlos Escartin, Adriano Zacarias, Josep Vegue, Domingos Katimba, María Carmen Vivas, Estevao Gabriel, María Concepción Marina, Jacobo Mendioroz, María Teresa López, Tomas Pumarola, Israel Molina, and María Teresa Tórtola
Table 2
Distribution of gene mutations associated with INH and RIF resistance, Cubal, Angola, April 2014–July 2015*
| Phenotypic resistance |
GenoType MTBDRplus |
Isolates from new cases |
Isolates from retreatment cases |
||
| katG |
inhA |
rpoB |
|||
| INH, n = 113 | 47 | 66 | |||
| ∆wt, S315T1 | – | 23 | 42 | ||
| ∆wt | – | 3 | 5 | ||
| – | ∆wt1, C15T | 2 | 2 | ||
| – | ∆wt1 | 0 | 1 | ||
| – | C15T | 0 | 1 | ||
| – |
– |
19 |
15 |
||
| RIF, n = 81 | 20 | 61 | |||
| – | 1 | 3 | |||
| Δwt2 | 0 | 2 | |||
| Δwt2,3,4, D516V | 1 | 8 | |||
| Δwt3,4, D516V | 3 | 3 | |||
| Δwt4,5 | 0 | 1 | |||
| Δwt7 | 0 | 1 | |||
| Δwt7, H526Y | 2 | 0 | |||
| Δwt7, H526D | 0 | 2 | |||
| Δwt7,8, H526D | 0 | 1 | |||
| Δwt8 | 1 | 3 | |||
| Δwt8, S531L | 12 | 37 | |||
*INH, isoniazid; RIF, rifampin; –, no mutation inside region.
1These authors were co-principal investigators for this article.
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