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Volume 24, Number 3—March 2018
Research

Characteristics Associated with Negative Interferon-γ Release Assay Results in Culture-Confirmed Tuberculosis Patients, Texas, USA, 2013–2015

Duc T. Nguyen, Larry D. Teeter, Julie Graves, and Edward A. GravissComments to Author 
Author affiliations: Houston Methodist Research Institute, Houston, Texas, USA (D.T. Nguyen, E.A. Graviss); Forensic Research and Analysis, Portland, Oregon, USA (L.D. Teeter); University of Medicine and Health Sciences, New York, New York, USA (J. Graves); University of Texas School of Public Health, Houston (J. Graves)

Main Article

Table 4

Cox proportional hazards model for association between 1-year survival from date of tuberculosis diagnosis and characteristics of culture-confirmed TB patients with negative IGRA results, by IGRA type, Texas, USA, 2013–2015*

Variable
All IGRA results, N = 1,343†
QFT only, n = 880†
T-SPOT.TB only, n = 463†
aHR (95% CI)
p value

aHR (95% CI)
p value

aHR (95% CI)
p value
Negative IGRA result 1.99 (1.18–3.33) 0.01 1.64 (0.88–3.08) 0.120 3.36 (1.27–8.90) 0.02
Age in years 1.06 (1.04–1.07) <0.001 1.06 (1.04–1.08) <0.001 1.05 (1.02–1.08) 0.001
Alcohol 1.55 (0.92–2.60) 0.10 1.75 (0.97–3.15) 0.06 1.19 (0.39–3.63) 0.76
HIV positive 5.00 (2.68–9.33) <0.001 4.79 (2.43–9.47) <0.001 4.38 (0.90–21.44) 0.07
Time from diagnosis to treatment 0.99 (0.99–1.00) 0.002 0.99 (0.99–1.00) 0.01 0.99 (0.98–1.00) 0.15

*aHR, adjusted hazard ratio; IGRA, interferon-γ release assay; QFT, QuantiFERON-TB Gold In-Tube.
†Cox proportional hazards models were run with data from patients having complete data sets for all the included variables; aHRs were from the multivariate Cox proportional hazards models.

Main Article

Page created: February 15, 2018
Page updated: February 15, 2018
Page reviewed: February 15, 2018
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