TY - JOUR AU - Isidro, Joana AU - Santos, Andrea AU - Nunes, Alexandra AU - Borges, Vítor AU - Silva, Catarina AU - Vieira, Luís AU - Mendes, Aristides AU - Serrano, Mónica AU - Henriques, Adriano AU - Gomes, João Paulo AU - Oleastro, Mónica T1 - Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal T2 - Emerging Infectious Disease journal PY - 2018 VL - 24 IS - 4 SP - 741 SN - 1080-6059 AB - We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance. KW - Clostridium difficile infection KW - imipenem resistance KW - penicillin-binding proteins KW - ribotype 017 KW - multidrug resistance KW - bacteria KW - antimicrobial resistance KW - Portugal KW - CDI KW - Clostridium difficile DO - 10.3201/eid2404.170095 UR - https://wwwnc.cdc.gov/eid/article/24/4/17-0095_article ER - End of Reference