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Volume 24, Number 4—April 2018
Research

Phenotypic and Genotypic Characterization of Enterobacteriaceae Producing Oxacillinase-48–Like Carbapenemases, United States

Joseph D. LutgringComments to Author , Wenming Zhu, Tom J.B. de Man, Johannetsy J. Avillan, Karen F. Anderson, David R. Lonsway, Lori A. Rowe, Dhwani Batra, J. Kamile Rasheed, and Brandi M. Limbago
Author affiliations: Emory University School of Medicine, Atlanta, Georgia, USA (J.D. Lutgring); Centers for Disease Control and Prevention, Atlanta (J.D. Lutgring, W. Zhu, T.J.B. de Man, J.J. Avillan, K.F. Anderson, D.R. Lonsway, L.A. Rowe, D. Batra, J.K. Rasheed, B.M. Limbago)

Main Article

Table 2

Phenotypic and genotypic characterization of Enterobacteriaceae harboring β-lactamase OXA-48−like carbapenemase, United States*

Isolate no. Species Year Source HHS region† MHT MEM mCIM Carba NP ST OXA allele NDM allele ESBLs
1 Klebsiella pneumoniae 2010 Urine 9 + + + ST34 181 None CTX-M-15
2 K. pneumoniae 2011 Urine 9 + + + ST34 181 None CTX-M-15
3 K. pneumoniae 2011 Urine 9 + + + ST34 181 None CTX-M-15
4 K. pneumoniae 2011 Urine 9 + + + ST34 181 None CTX-M-15
5 K. pneumoniae 2011 Respiratory 9 + + + ST34 181 None CTX-M-15
6 K. ozaenae 2011 Respiratory 9 + + + None 181 None CTX-M-15
7 K. pneumoniae 2011 Wound 10 + + + ST14 232 None CTX-M-15
8 K. pneumoniae 2012 Peritoneal fluid 3 + + – ST43 181 None CTX-M-15
9 K. pneumoniae 2012 Urine 5 + + + ST14 232 1 CTX-M-15
10 K. pneumoniae 2012 Rectal swab 5 + + + ST14 232 1 CTX-M-15
11 K. pneumoniae 2013 Urine 3 + + + ST14 232 1 CTX-M-15
12 K. pneumoniae 2013 Respiratory 3 + + + ST14 232 1 CTX-M-15
13 K. pneumoniae 2013 Respiratory 5 + + Ind ST147 181 None CTX-M-15
14 Enterobacter aerogenes 2013 Peritoneal fluid 3 + + + None 48 None None
15 K. pneumoniae 2013 Urine 6 + + – ST16 232 None CTX-M-15
16 K. pneumoniae 2013 Urine 6 + + – ST16 232 None CTX-M-15
17 K. pneumoniae 2013 Urine 6 + + Ind ST16 232 None CTX-M-15
18 K. pneumoniae 2013 Urine 5 + + + ST14 232 None CTX-M-15
19 K. pneumoniae 2013 Respiratory 5 + + Ind ST43 181 None CTX-M-15
20 K. pneumoniae 2013 Respiratory 5 + + + ST43 181 None CTX-M-15
21 K. pneumoniae 2013 Urine 5 + + + ST15 48 None CTX-M-15
22 K. pneumoniae 2014 Respiratory 1 + + + ST437 232 5 CTX-M-15, SHV-12
23 K. pneumoniae 2014 Respiratory 5 + + + ST14 48 None CTX-M-14b, CTX-M-15
24 Escherichia coli 2014 Urine 2 + + – None 181 None None
25 K. pneumoniae 2014 Urine 2 + + + ST36 48 None None
26 K. pneumoniae 2013 Urine 9 + + + ST34 181 None CTX-M-15
27 K. pneumoniae 2013 Urine 9 + + Ind ST34 181 None CTX-M-15
28 K. pneumoniae 2014 Respiratory 4 + + + ST101 48 None CTX-M-15
29 K. pneumoniae 2014 Respiratory 4 + + + ST101 48 None CTX-M-15
30 K. pneumoniae 2014 Unknown 4 + + + ST101 48 None CTX-M-15

*ESBLs, extended-spectrum β-lactamases; HHS, Health and Human Services; Ind, indeterminate; mCIM, modified carbapenem inactivation method; MEM, meropenem; MHT, modified Hodge test; NDM, New Delhi metallo-β-lactamase gene; NP, Nordmann–Poirel; OXA, oxacillinase; ST, sequence type (by multilocus sequence typing); –, negative; +, positive.
†HHS regions: 1, Connecticut, Maine, Massachusetts, New Hampshire, Rhode Island, Vermont; 2, New Jersey, New York; 3, Delaware, District of Columbia, Maryland, Pennsylvania, Virginia, West Virginia; 4, Alabama, Florida, Georgia, Kentucky, Mississippi, North Carolina, South Carolina, Tennessee; 5, Illinois, Indiana, Michigan, Minnesota, Ohio, Wisconsin; 6, Arkansas, Louisiana, New Mexico, Oklahoma, Texas; 7, Iowa, Kansas, Missouri, Nebraska; 8, Colorado, Montana, North Dakota, South Dakota, Utah, Wyoming; 9, Arizona, California, Hawaii, Nevada; 10, Alaska, Idaho, Oregon, Washington.

Main Article

Page created: July 31, 2018
Page updated: July 31, 2018
Page reviewed: July 31, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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