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Volume 24, Number 4—April 2018
Research

Phenotypic and Genotypic Characterization of Enterobacteriaceae Producing Oxacillinase-48–Like Carbapenemases, United States

Joseph D. LutgringComments to Author , Wenming Zhu, Tom J.B. de Man, Johannetsy J. Avillan, Karen F. Anderson, David R. Lonsway, Lori A. Rowe, Dhwani Batra, J. Kamile Rasheed, and Brandi M. Limbago
Author affiliations: Emory University School of Medicine, Atlanta, Georgia, USA (J.D. Lutgring); Centers for Disease Control and Prevention, Atlanta (J.D. Lutgring, W. Zhu, T.J.B. de Man, J.J. Avillan, K.F. Anderson, D.R. Lonsway, L.A. Rowe, D. Batra, J.K. Rasheed, B.M. Limbago)

Main Article

Table 4

Plasmid transformation of Enterobacteriaceae producing OXA-48–like carbapenemases, United States*

Isolate no.† MIC, μg/mL
MHT MEM OXA allele Plasmid replicon type ESBL CTX-M
ETP MEM CRO TZP AMK
R <0.12 <0.12 <1 <4 <1
7 >8 >8 >32 >128 32 + 232 ColKP3, IncR, IncFIB(pQIL) 15
7T >8 4 <1 >128 <1 + 232 ColKP3
9 >8 >8 >32 >128 >64 + 232 ColKP3, IncR, IncHI1B, IncFIB(K) 15
9T >8 8 <1 >128 <1 + 232 ColKP3
11 >8 >8 >32 >128 >64 + 232 ColKP3, IncR, IncHI1B, IncFIB(K) 15
11T >8 8 ≤1 >128 <1 + 232 ColKP3
23 >8 4 >32 >128 64 + 48 IncL/M 14b, 15
23T 4 1 >32 >128 16 + 48 IncL/M 14b
25 >8 8 2 >128 <1 + 48 IncL/M
25T >8 8 <1 >128 <1 + 48 IncL/M
28 >8 >8 >32 >128 8 + 48 IncL/M, IncR, ColRNAI
28T >8 8 <1 128 <1 + 48 IncL/M

*AMK, amikacin; CRO, ceftriaxone; ESBL, extended-spectrum β-lactamase; ETP, ertapenem; MEM, meropenem; MHT, modified Hodge test; OXA, oxacillinase; R, recipient strain before transformation (Escherichia coli DH10B); T, transformant; TZP, piperacillin/tazobactam; –, negative; +, positive.
†Isolates 1, 2, 26, and 27 did not have any transformants.

Main Article

Page created: July 31, 2018
Page updated: July 31, 2018
Page reviewed: July 31, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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