Volume 24, Number 4—April 2018
Research
Genomic Surveillance of 4CMenB Vaccine Antigenic Variants among Disease-Causing Neisseria meningitidis Isolates, United Kingdom, 2010–2016
Charlene M.C. Rodrigues
, Jay Lucidarme, Ray Borrow, Andrew Smith, J. Claire Cameron, E. Richard Moxon, and Martin C.J. Maiden
, Jay Lucidarme, Ray Borrow, Andrew Smith, J. Claire Cameron, E. Richard Moxon, and Martin C.J. Maiden
Table 1
Geographic distribution of culture-confirmed invasive meningococcal disease isolates that have undergone whole- genome sequencing, United Kingdom, 2010–2016*
| 1 | 2 | 3 | 4 | Total | PHE | PHS | A | B | C | E | NG | W | W/Y | X | Y | Z | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2010−11 | 464 | 37 | 36 | 13 | 550 | 1,009 (46.0) | 76 (47.4) | 1 | 423 | 13 | 1 | 5 | 27 | 2 | 1 | 76 | 1 | ||
| 2011−12 | 370 | 28 | 30 | 11 | 439 | 730 (50.7) | 56 (53.6) | 0 | 311 | 18 | 1 | 4 | 32 | 1 | 0 | 72 | 0 | ||
| 2012−13 | 415 | 29 | 34 | 13 | 491 | 769 (54.0) | 66 (51.5) | 0 | 325 | 29 | 0 | 7 | 51 | 1 | 0 | 78 | 0 | ||
| 2013−14 | 367 | 27 | 30 | 12 | 436 | 636 (57.7) | 60 (50.0) | 0 | 240 | 24 | 0 | 1 | 92 | 2 | 0 | 77 | 0 | ||
| 2014−15 | 483 | 19 | 55 | 15 | 572 | 724 (66.7) | 65 (84.6) | 0 | 283 | 23 | 0 | 5 | 172 | 2 | 0 | 87 | 0 | ||
| 2015−16 |
488 |
23 |
62 |
12 |
585 |
805 (60.6) |
99 (62.6) |
0 |
238 |
34 |
2 |
8 |
197 |
2 |
0 |
104 |
0 |
||
| Total |
2,587 |
163 |
247 |
76 |
3,073 |
4,673 (55.4) |
442 (55.9) |
1 |
1,820 |
141 |
4 |
30 |
571 |
10 |
1 |
494 |
1 |
||
| *Laboratory-confirmed cases included culture-confirmed and PCR-confirmed cases. Data included in this study represented 55.4% of all laboratory-confirmed cases in England and 55.9% of those in Scotland. NG, nongroupable; PHE, Public Health England; PHS, Public Health Scotland. †1, England; 2, Wales; 3, Scotland; 4, Northern Ireland. ‡W/Y serogroups were combined because of inconclusive serogrouping results. | |||||||||||||||||||
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Page updated: March 19, 2018
Page reviewed: March 19, 2018
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