TY - JOUR AU - Rodrigues, Charlene M.C. AU - Lucidarme, Jay AU - Borrow, Ray AU - Smith, Andrew AU - Cameron, J. Claire AU - Moxon, E. Richard AU - Maiden, Martin C.J. T1 - Genomic Surveillance of 4CMenB Vaccine Antigenic Variants among Disease-Causing Neisseria meningitidis Isolates, United Kingdom, 2010–2016 T2 - Emerging Infectious Disease journal PY - 2018 VL - 24 IS - 4 SP - 673 SN - 1080-6059 AB - In September 2015, 4CMenB meningococcal vaccine was introduced into the United Kingdom infant immunization program without phase 3 trial information. Understanding the effect of this program requires enhanced surveillance of invasive meningococcal disease (IMD) Neisseria meningitidis isolates and comparison with prevaccination isolates. Bexsero Antigen Sequence Types (BASTs) were used to analyze whole-genome sequences of 3,073 prevaccine IMD N. meningitidis isolates obtained during 2010−2016. Isolates exhibited 803 BASTs among 31 clonal complexes. Frequencies of antigen peptide variants were factor H binding protein 1, 13.4%; Neisserial heparin-binding antigen 2, 13.8%; Neisseria adhesin A 8, 0.8%; and Porin A-VR2:P1.4,10.9%. In 2015−16, serogroup B isolates showed the highest proportion (35.7%) of exact matches to >1 Bexsero components. Serogroup W isolates showed the highest proportion (93.9%) of putatively cross-reactive variants of Bexsero antigens. Results highlighted the likely role of cross-reactive antigens. BAST surveillance of meningococcal whole-genome sequence data is rapid, scalable, and portable and enables international comparisons of isolates. KW - Neisseria meningitidis KW - bacteria KW - genomic surveillance KW - molecular epidemiology KW - multilocus sequence typing KW - MLST KW - meningococcal vaccines KW - 4CMenB KW - vaccine KW - antigenic variants KW - meningitis/encephalitis KW - invasive meningococcal disease KW - IMD KW - whole genome-sequencing KW - United Kingdom KW - meningococci KW - vaccines KW - Bexsero KW - vaccine antigenic variants KW - whole-genome sequencing KW - epidemiologic year DO - 10.3201/eid2404.171480 UR - https://wwwnc.cdc.gov/eid/article/24/4/17-1480_article ER - End of Reference