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Volume 24, Number 5—May 2018
Research

Dynamics of Spirochetemia and Early PCR Detection of Borrelia miyamotoi

Lyudmila Karan, Marat MakenovComments to Author , Nadezhda Kolyasnikova, Olga Stukolova, Marina Toporkova, and Olga Olenkova
Author affiliations: Central Research Institute of Epidemiology, Moscow, Russia (L. Karan, M. Makenov, N. Kolyasnikova, O. Stukolova); Medical Association Novaya Bolnitsa, Yekaterinburg, Russia (M. Toporkova); Clinical Diagnostic Center, Yekaterinburg (O. Olenkova)

Main Article

Table 2

Dynamics of Borrelia miyamotoi RNA and DNA load in blood samples from 23 patients with Borrelia miyamotoi disease, Yekaterinburg, Russia, 2010 and 2015*

Year and patient ID PCR product for B. miyamotoi, copies/mL
Day 1
Day 2
Day 3
Day 4
Day 5
RNA DNA RNA DNA RNA DNA RNA DNA RNA DNA
2010










1 NA NA 1.9 × 104 3.3 × 104 NA NA NA NA
2 NA NA 1.9 × 104 5.5 × 104 NA NA NA NA 3.1 × 103 2.7 × 104
3 NA NA 2.0 × 103 2.4 × 103
4 NA NA 9.5 × 102 3.4 × 103 3.4 × 102 7.1 × 102
5 NA NA 1.6 × 103 1.2 × 104 8.5 × 101
6 NA NA NA NA 1.1 × 103 2.6 × 104 NA NA
7 NA NA 6.7 × 103 2.7 × 104 NA NA NA NA
8 NA NA 6.5 × 102 2.8 × 103 NA NA NA NA
9 NA NA 9.9 × 103 1.7 × 104 NA NA NA NA
2015
10 NA NA 1.2 × 104 8.2 × 103 2.2 × 101
11 NA NA 2.8 × 105 9.2 × 104 1.0 × 103 3.2 × 102
12 NA NA 5.4 × 104 1.7 × 104
13 NA NA 8.7 × 104 8.8 × 103
14 NA NA 6.1 × 104 3.2 × 104 NA NA
15 NA NA NA NA 1.8 × 103 1.3 × 103 NA NA NA NA
16 2.0 × 104 1.9 × 104 NA NA NA NA 2.0 × 102 1.3 × 101 NA NA
17 NA NA NA NA 3.4 × 103 6.9 × 102
18 NA NA 1.9 × 104 7.2 × 104
19 NA NA 4.3 × 104 1.4 × 104 9.7 × 101 3.0 × 101
20 NA NA 4.2 × 105 9.6 × 104 3.2 × 102 8.0 × 101
21 NA NA 2.9 × 102 6.5 × 101
22 NA NA NA NA 3.3 × 102 2.3 × 103
23 NA NA NA NA 1.3 × 104 4.1 × 103 NA NA

*Day indicates day after onset of symptoms. Bold indicates day of starting antimicrobial drug therapy (ceftriaxone). For patients 1, 4, 9, 17, 19, and 22, antimicrobial drug therapy was started on day 6 or later. ID, patient identification; NA, not available (blood sample was not obtained); –, negative.

Main Article

Page created: April 17, 2018
Page updated: April 17, 2018
Page reviewed: April 17, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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