Volume 24, Number 5—May 2018
Antimicrobial-Resistant Bacteria in Infected Wounds, Ghana, 20141
|Drug resistance||% Resistant
|Proteus mirabilis, n = 20||Eshcerichia coli, n = 19||Klebsiella pneumoniae, n = 13||Enterobacter cloacae complex, n = 10|
|CTX-S + CIP-S||80.0||42.1||53.8||60.0|
|CTX-S + CIP-R||15.0||10.5||ND||ND|
|CTX-R + CIP-S||ND||5.3||ND||10.0|
|CTX-R + CIP-R||5.0||42.1||46.2||30.0|
*Antimicrobial susceptibility testing was performed by using VITEK 2 (bioMérieux, Marcy-l'Étoile, France) according to the EUCAST breakpoint tables for interpretation of MICs, version 4.0, 2014 (7). CIP, ciprofloxacin; CTX, cefotaxime; ND, not detected; R, resistant; S, susceptible.
- Vernet G, Mary C, Altmann DM, Doumbo O, Morpeth S, Bhutta ZA, et al. Surveillance for antimicrobial drug resistance in under-resourced countries. Emerg Infect Dis. 2014;20:434–41.
- Gross U, Amuzu SK, de Ciman R, Kassimova I, Gross L, Rabsch W, et al. Bacteremia and antimicrobial drug resistance over time, Ghana. Emerg Infect Dis. 2011;17:1879–82.
- Kumburu HH, Sonda T, Mmbaga BT, Alifrangis M, Lund O, Kibiki G, et al. Patterns of infections, aetiological agents and antimicrobial resistance at a tertiary care hospital in northern Tanzania. Trop Med Int Health. 2017;22:454–64.
- Sen CK, Gordillo GM, Roy S, Kirsner R, Lambert L, Hunt TK, et al. Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regen. 2009;17:763–71.
- Leopold SJ, van Leth F, Tarekegn H, Schultsz C. Antimicrobial drug resistance among clinically relevant bacterial isolates in sub-Saharan Africa: a systematic review. J Antimicrob Chemother. 2014;69:2337–53.
- Cheesbrough M. District laboratory practice in tropical countries. Part 2. 2nd ed. Cambridge (UK): Cambridge University Press; 2006.
- The European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 4.0. 2014 [cited 2017 Sep 9]. http://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Breakpoint_tables/Breakpoint_table_v_4.0.pdf
- Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing: twenty-fourth informational supplement (M100–S24). Wayne (PA): The Institute; 2014.
- Nwankwo E, Edino S. Seasonal variation and risk factors associated with surgical site infection rate in Kano, Nigeria. Turk J Med Sci. 2014;44:674–80.
- Ntirenganya C, Manzi O, Muvunyi CM, Ogbuagu O. High prevalence of antimicrobial resistance among common bacterial isolates in a tertiary healthcare facility in Rwanda. Am J Trop Med Hyg. 2015;92:865–70.
- Manyahi J, Matee MI, Majigo M, Moyo S, Mshana SE, Lyamuya EF. Predominance of multi-drug resistant bacterial pathogens causing surgical site infections in Muhimbili National Hospital, Tanzania. BMC Res Notes. 2014;7:500.
- Mengesha RE, Kasa BG, Saravanan M, Berhe DF, Wasihun AG. Aerobic bacteria in post surgical wound infections and pattern of their antimicrobial susceptibility in Ayder Teaching and Referral Hospital, Mekelle, Ethiopia. BMC Res Notes. 2014;7:575.
- Falagas ME, Karageorgopoulos DE, Leptidis J, Korbila IP. MRSA in Africa: filling the global map of antimicrobial resistance. PLoS One. 2013;8:e68024.
- Morgan DJ, Okeke IN, Laxminarayan R, Perencevich EN, Weisenberg S. Non-prescription antimicrobial use worldwide: a systematic review. Lancet Infect Dis. 2011;11:692–701.
- Elder DP, Kuentz M, Holm R. Antibiotic resistance: the need for a global strategy. J Pharm Sci. 2016;105:2278–87.
1Preliminary results from this study were presented at the Annual Meeting of the German Society of Tropical Medicine and International Health; October 7–8, 2016; Bonn, Germany; and at the 69th Annual Meeting of the German Society for Hygiene and Microbiology; March 5–8, 2017; Wuerzburg, Germany.
2These authors contributed equally to this article.