TY - JOUR AU - Fox-Lewis, Andrew AU - Takata, Junko AU - Miliya, Thyl AU - Lubell, Yoel AU - Soeng, Sona AU - Sar, Poda AU - Rith, Kolthida AU - McKellar, Gregor AU - Wuthiekanun, Vanaporn AU - McGonagle, Erin AU - Stoesser, Nicole AU - Moore, Catrin AU - Parry, Christopher AU - Turner, Claudia AU - Day, Nicholas P.J. AU - Cooper, Ben AU - Turner, Paul T1 - Antimicrobial Resistance in Invasive Bacterial Infections in Hospitalized Children, Cambodia, 2007–2016 T2 - Emerging Infectious Disease journal PY - 2018 VL - 24 IS - 5 SP - 841 SN - 1080-6059 AB - To determine trends, mortality rates, and costs of antimicrobial resistance in invasive bacterial infections in hospitalized children, we analyzed data from Angkor Hospital for Children, Siem Reap, Cambodia, for 2007–2016. A total of 39,050 cultures yielded 1,341 target pathogens. Resistance rates were high; 82% each of Escherichia coli and Klebsiella pneumoniae isolates were multidrug resistant. Hospital-acquired isolates were more often resistant than community-acquired isolates; resistance trends over time were heterogeneous. K. pneumoniae isolates from neonates were more likely than those from nonneonates to be resistant to ampicillin–gentamicin and third-generation cephalosporins. In patients with community-acquired gram-negative bacteremia, third-generation cephalosporin resistance was associated with increased mortality rates, increased intensive care unit admissions, and 2.26-fold increased healthcare costs among survivors. High antimicrobial resistance in this setting is a threat to human life and the economy. In similar low-resource settings, our methods could be reproduced as a robust surveillance model for antimicrobial resistance. KW - antimicrobial resistance KW - Cambodia KW - children KW - bacteria KW - invasive infections KW - hospital DO - 10.3201/eid2405.171830 UR - https://wwwnc.cdc.gov/eid/article/24/5/17-1830_article ER - End of Reference