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Volume 24, Number 6—June 2018
CME ACTIVITY - Research

Occupation-Associated Fatal Limbic Encephalitis Caused by Variegated Squirrel Bornavirus 1, Germany, 2013

Dennis TappeComments to Author , Kore Schlottau, Daniel Cadar, Bernd Hoffmann, Lorenz Balke, Burkhard Bewig, Donata Hoffmann, Philip Eisermann, Helmut Fickenscher, Andi Krumbholz, Helmut Laufs, Monika Huhndorf, Maria Rosenthal, Walter Schulz-Schaeffer, Gabriele Ismer, Sven-Kevin Hotop, Mark Brönstrup, Anthonina Ott, Jonas Schmidt-Chanasit1, and Martin Beer1
Author affiliations: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany (D. Tappe, D. Cadar, P. Eisermann, M. Rosenthal, J. Schmidt-Chanasit); Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany (K. Schlottau, B. Hoffmann, D. Hoffmann, M. Beer); University Medical Center Schleswig-Holstein, Kiel, Germany (L. Balke, B. Bewig, H. Laufs, M. Huhndorf); Christian-Albrecht University of Kiel and University Medical Center, Kiel (H. Fickenscher, A. Krumbholz); Saarland University Medical Center, Homburg, Germany (W. Schulz-Schaeffer); Zoological Garden, Schleswig-Holstein, Germany (G. Ismer); Helmholtz Centre for Infection Research and German Centre for Infection Research, Braunschweig, Germany (S.-K. Hotop, M. Brönstrup); Euroimmun AG, Lübeck, Germany (A. Ott); German Centre for Infection Research, Hamburg (J. Schmidt-Chanasit)

Main Article

Figure 1

Magnetic resonance imaging of the brain throughout the course of the disease in patient who died of limbic encephalitis caused by variegated squirrel bornavirus 1 (VSBV-1), Germany, 2013. A) T2-weighted transversal image at admission showing no pathologic changes. B) T2-weighted image 3 weeks after admission showing edema in limbic structures (insula, hippocampus, anterior cingulate) and in the basal ganglia. C) T2-weighted image 4 weeks after admission showing progressive edema. Additional myel

Figure 1. Magnetic resonance imaging of the brain throughout the course of the disease in patient who died of limbic encephalitis caused by variegated squirrel bornavirus 1 (VSBV-1), Germany, 2013. A) T2-weighted transversal image at admission showing no pathologic changes. B) T2-weighted image 3 weeks after admission showing edema in limbic structures (insula, hippocampus, anterior cingulate) and in the basal ganglia. C) T2-weighted image 4 weeks after admission showing progressive edema. Additional myelopathy extended from the medulla down into the thoracic segments (not shown). D) FLAIR image 4 weeks after admission showing edema in the anterior cingulate cortex. E) T1-weighted image 4 weeks after admission without contrast showing slight hemorrhage in the basal ganglia.

Main Article

1These authors contributed equally to this article.

Page created: May 18, 2018
Page updated: May 18, 2018
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