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Volume 24, Number 7—July 2018

Pneumococcal Meningitis in Adults after Introduction of PCV7 and PCV13, Israel, July 2009–June 20151

Gili Regev-YochayComments to Author , Klaris Reisenberg, Michal Katzir, Yonit Wiener-Well, Galia Rahav, Jacob Strahilevitz, Valery Istomin, Evgenia Tsyba, Avi Peretz, Shirley Khakshoor, Ron Dagan, on behalf of the Israeli Adult Invasive Pneumococcal Disease Group
Author affiliations: Sheba Medical Center, Ramat Gan, Israel (G. Regev-Yochay, G. Rahav, S. Khakshoor); Tel Aviv University, Tel Aviv, Israel (G. Regev-Yochay, M. Katzir, G. Rahav); Soroka Medical Center, Beersheba, Israel (K. Reisenberg); Bar-Ilan University, Safed, Israel (K. Reisenberg, A. Peretz); Meir Medical Center, Kfar Saba, Israel (M. Katzir); Shaare Zedek Medical Center, Jerusalem, Israel (Y. Wiener-Well); Hadassah-Hebrew University, Jerusalem (J. Strahilevitz); Hillel Yaffe Medical Center, Hadera, Israel (V. Istomin); Barzilai Medical Center, Ashkelon, Israel (E. Tsyba); Baruch Padeh Medical Center, Tiberias, Israel (A. Peretz); Ben-Gurion University of the Negev, Beersheba (R. Dagan)

Main Article

Table 2

Univariate analysis of clinical outcomes of meningitis versus nonmeningitis IPD patients, Israel, July 1, 2009–June 30, 2015*

Category Pneumococcal meningitis, 
n = 221 Nonmeningitis IPD, n = 2,124 p value
Population with full data available 213 2,123
Overall no. deaths (case-fatality rate) 33 (15.5) 488 (23.0) 0.0123
ICU admission 115 (54.0) 322 (15.2) <0.0001
Ventilation required 91 (42.7) 405 (19.1) <0.0001
Mean LOS, d†
Percentile LOS, by days, %
5 55 33
10 38.5 21
25 21 11
50 15 6
75 12 4

Sepsis† 10/180 (5.6) 170/1,635 (10.4) 0.0391
Discharged to long-term care facility† 34/173 (19.7) 104/1,490 (7.0) <0.0001

*Values are no. (%) except as indicated. ICU, intensive care unit; IPD, invasive pneumococcal disease; LOS, length of stay.
†Outcome assessed only for those who were discharged (deaths were excluded).

Main Article

1Some results from this study were presented at the 10th International Symposium on Pneumococci and Pneumococcal Diseases, June 26–30, 2016, Glasgow, Scotland.

2Additional members of the Israeli Adult Invasive Pneumococcal Disease Group are listed at the end of this article.

Page created: June 18, 2018
Page updated: June 18, 2018
Page reviewed: June 18, 2018
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