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Volume 24, Number 7—July 2018

Use of Urea Wash ELISA to Distinguish Zika and Dengue Virus Infections

Wen-Yang Tsai, Han Ha Youn, Jasmine Tyson, Carlos Brites, Jih-Jin Tsai, Celia Pedroso, Jan Felix Drexler, Angel Balmaseda, Eva Harris, and Wei-Kung WangComments to Author 
Author affiliations: University of Hawaii at Manoa, Honolulu, Hawaii, USA (W.-Y. Tsai, H.H. Youn, J. Tyson, W.-K. Wang); Federal University of Bahia, Salvador, Brazil (C. Brites, C. Pedroso); Kaohsiung Medical University, Kaohsiung, Taiwan (J.-J. Tsai); University of Bonn Medical Centre, Bonn, Germany (J.F. Drexler); National Center for Diagnosis and Reference, Ministry of Health, Managua, Nicaragua (A. Balmaseda); University of California at Berkeley, Berkeley, California, USA (E. Harris)

Main Article


Sampling time, serotype, and sources of serum/plasma panels in study of use of urea wash ELISA to distinguish Zika and dengue virus infections*

Panel sample collection times Category Sampling time after symptom onset, mean (range) No. patients Source (no. patients) and year(s) of sample collection Shown in
Single time point
pDENV-1 Convalescent to postconvalescent 138 (19−263) d 16 Taiwan (4), 2001–2002; Hawaii, USA (12), 2015 Figure 1
pZIKV Convalescent 17 (14−24) d 20 Nicaragua, 2016 Figure 1
sDENV Convalescent 14 (8−35) d 24 Taiwan, 2001–2002 Figure 1
DENV-ZIKV Convalescent 16 (14−19) d 20 Nicaragua, 2016 Figure 1
Probable DENV-ZIKV Convalescent 10 (6−14) d 19 Brazil, 2015–2016 Figure 1
sDENV Postconvalescent 3.2 (3−4) mo 6 Taiwan (2), 2006–2009; Nicaragua (4), 2006–2008 Figure 2
sDENV Postconvalescent 12 (12−12) mo 18 Nicaragua, 2006–2008 Figure 2
sDENV Postconvalescent 19.7 (18−24) mo 14 Taiwan (10), 2006–2009; Nicaragua (4), 2006–8 Figure 2
71 (67−72) mo
Taiwan, 2006–2009
Figure 2
Sequential time points
sDENV Postconvalescent 10 (3−18) mo 3 Nicaragua, 2006–2008 Figure 2

*DENV-ZIKV, ZIKV infection with previous dengue; pDENV-1, primary dengue virus 1 infection; pZIKV, primary Zika virus infection; sDENV, secondary dengue virus infection.
†3–4 samples/patient.

Main Article

Page created: June 18, 2018
Page updated: June 18, 2018
Page reviewed: June 18, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.