TY - JOUR AU - Tsai, Wen-Yang AU - Youn, Han Ha AU - Tyson, Jasmine AU - Brites, Carlos AU - Tsai, Jih-Jin AU - Pedroso, Celia AU - Drexler, Jan Felix AU - Balmaseda, Angel AU - Harris, Eva AU - Wang, Wei-Kung T1 - Use of Urea Wash ELISA to Distinguish Zika and Dengue Virus Infections T2 - Emerging Infectious Disease journal PY - 2018 VL - 24 IS - 7 SP - 1355 SN - 1080-6059 AB - Serologic testing remains crucial for Zika virus diagnosis. We found that urea wash in a Zika virus nonstructural protein 1 IgG ELISA distinguishes secondary dengue virus infection from Zika virus infection with previous dengue (sensitivity 87.5%, specificity 93.8%). This test will aid serodiagnosis, serosurveillance, and monitoring of Zika complications in dengue-endemic regions. KW - Zika virus KW - dengue virus KW - nonstructural protein 1 KW - serologic test KW - urea KW - viruses DO - 10.3201/eid2407.171170 UR - https://wwwnc.cdc.gov/eid/article/24/7/17-1170_article ER - End of Reference