Volume 24, Number 7—July 2018
Research
Molecular Epidemiology of Human Adenovirus–Associated Febrile Respiratory Illness in Soldiers, South Korea1
Jung Yeon Heo2, Ji Yun Noh2, Hye Won Jeong, Kang-Won Choe, Joon Young Song, Woo Joo Kim, and Hee Jin Cheong
Table 3
Comparison of demographic and clinical features of soldiers with acute febrile respiratory illness, by HAdV type 55 infection status, South Korea, January 2013–April 2014*
| Characteristic |
HAdV-55 infection status |
OR (95% CI) |
p value |
|
|---|---|---|---|---|
| HAdV-55, n = 29 |
Non–HAdV-55, n = 11 | |||
| Age, y, mean +SD | 21.41 +1.92 | 21.18 +1.40 | NA | 0.717† |
| New recruits |
12 (41.4) |
5 (45.5) |
0.84 (0.21–3.43) |
0.816‡ |
| Signs and symptoms at presentation | ||||
| Fever >5 d | 17 (58.6) | 5 (45.5) | 1.70 (0.42–6.88) | 0.455‡ |
| Nausea/vomiting | 5 (17.2) | 2 (18.2) | 0.93 (0.15–5.73) | 1.000§ |
| Diarrhea | 6 (20.7) | 3 (27.3) | 0.70 (0.14–3.45) | 0.686§ |
| Dyspnea/tachypnea | 8 (27.6) | 1 (9.1) | 3.81 (0.42–34.8) | 0.399§ |
| Conjunctival injection |
4 (13.8) |
2 (18.2) |
0.72 (0.11–4.63) |
1.000§ |
| Laboratory findings, mean +SD | ||||
| Leukocyte count, cells/μL | 5,200 +1,818 | 6,322 +2,656 | NA | 0.134† |
| Platelet count, × 103 cells/μL | 177 +57 | 172 +77 | NA | 0.848† |
| C-reactive protein, mg/dL |
6.7 +3.9 |
5.0 +1.8 |
NA |
0.193† |
| Radiographic findings | ||||
| Bilateral involvement | 6 (20.7) | 1 (9.1) | 2.61 (0.28–24.59) | 0.650§ |
| Consolidation | 11 (37.9) | 2 (18.2) | 2.75 (0.50–15.14) | 0.286§ |
| Patchy infiltration | 3 (10.3) | 1 (9.1) | 1.15 (0.11–12.44) | 1.000§ |
| Effusion |
3 (10.3) |
1 (9.1) |
1.15 (0.11–12.44) |
1.000§ |
| Clinical diagnosis | ||||
| Pharyngitis | 12 (41.4) | 5 (45.5) | 0.85 (0.21–3.43) | 0.815‡ |
| Tracheobronchitis | 4 (13.8) | 3 (27.3) | 0.43 (0.08–2.33) | 0.369§ |
| Pneumonia |
13 (44.8) |
3 (27.3) |
2.17 (0.48–9.86) |
0.473§ |
| Co-identified bacteria | 2 (6.9) | 1 (9.1) | 0.74 (0.06–9.09) | 1.000§ |
| Streptococcus pneumoniae | 1 (3.4) | 1 (9.1) | – | – |
| Mycoplasma pneumoniae |
1 (3.4) |
0 |
– |
– |
| Co-identified viruses | 5 (17.2) | 1 (9.1) | 2.08 (0.22–20.17) | 1.000§ |
| Rhinovirus | 3 (10.3) | 0 | – | – |
| Coronavirus | 1 (3.4) | 1 (9.1) | – | – |
| Parainfluenza virus | 1 (3.4) | 0 | – | – |
| Metapneumovirus |
1 (3.4) |
0 |
– |
– |
| Hospitalized patients | 25 (86.2) | 6 (54.5) | 5.21 (1.06–25.50) | 0.083§ |
| Admission to the intensive care unit | 7 (24.1) | 0 | NA | 0.159§ |
| Acute respiratory distress syndrome | 5 (17.2) | 0 | NA | 0.298§ |
| Length of hospital stay, d, mean +SD | 16.2 +9.9 | 14.6 +5.6 | NA | 0.619† |
| Death | 0 | 0 | NA | NA |
*Values are no. (%) soldiers except as indicated. HAdV, human adenovirus; NA, not available; OR, odds ratio; –, not applicable.
†By Student t-test.
‡By χ2 test.
§By Fisher exact test.
1Preliminary results from this study were presented at the European Congress of Clinical Microbiology and Infectious Diseases 2015, convened April 25–28, 2015, in Copenhagen, Denmark.
2These authors contributed equally to this article.
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