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Volume 24, Number 7—July 2018
Research

Diversity of Influenza A(H5N1) Viruses in Infected Humans, Northern Vietnam, 2004–2010

Hirotaka Imai1, Jorge M. Dinis1, Gongxun Zhong, Louise H. Moncla, Tiago J.S. Lopes, Ryan McBride, Andrew J. Thompson, Wenjie Peng, Mai thi Q. Le, Anthony Hanson, Michael Lauck, Yuko Sakai-Tagawa, Shinya Yamada, Julie Eggenberger, David H. O’Connor, Yasuo Suzuki, Masato Hatta, James C. Paulson, Gabriele Neumann, and Yoshihiro KawaokaComments to Author 
Author affiliations: University of Wisconsin, Madison, Wisconsin, USA (H. Imai, J.M. Dinis, G. Zhong, L.H. Moncla, T.J.S. Lopes, A. Hanson, M. Lauck, J. Eggenberger, D.H. O’Connor, M. Hatta, G. Neumann, T.C. Friedrich, Y. Kawaoka); The Scripps Research Institute, La Jolla, California, USA (R. McBride, A.J. Thompson, W. Peng, J.C. Paulson); National Institute of Hygiene and Epidemiology, Hanoi, Vietnam (M.t.Q. Le); University of Tokyo, Tokyo, Japan (Y. Sakai-Tagawa, S. Yamada, Y. Kawaoka); Chubu University, Kasugai, Japan (Y. Suzuki)

Main Article

Figure 3

Glycan microarray analysis of selected influenza A(H5N1) virus isolates from humans, northern Vietnam, 2004–2010. The labeled viruses were applied to a microarray that included α2,3-linked (blue) and α2,6-linked (red) glycans, which are indicated by numbers on the x-axis (online Technical Appendix Figure 1, https://wwwnc.cdc.gov/EID/article/24/7/17-1441-Techapp1.pdf). Shown are the binding signals with error bars reflecting SEMs calculated from 4 of 6 replicates on the array after discarding the

Figure 3. Glycan microarray analysis of selected influenza A(H5N1) virus isolates from humans, northern Vietnam, 2004–2010. The labeled viruses were applied to a microarray that included α2,3-linked (blue) and α2,6-linked (red) glycans, which are indicated by numbers on the x-axis (online Technical Appendix Figure 1, https://wwwnc.cdc.gov/EID/article/24/7/17-1441-Techapp1.pdf). Shown are the binding signals with error bars reflecting SEMs calculated from 4 of 6 replicates on the array after discarding the highest and lowest signals; note that the scales on the y-axis (relative fluorescence) vary because of differences in binding strength: A) CA04/UT3040I/II-HA; B) CA04/UT3040I-HA-138V; C) CA04/UT3040II-HA-186K; D) CA04/UT36250I/II-HA; E) CA04/UT36250I/II-HA-138V; F) CA04/UT36282I/II-HA; G) CA04/UT36282I/II-HA-138V/A; H) CA04/K173; I) Brisbane/10/2007.

Main Article

1These authors contributed equally to this article.

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