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Volume 24, Number 8—August 2018
Dispatch

Distinguishing Zika and Dengue Viruses through Simple Clinical Assessment, Singapore

Gabriel Yan1, Long Pang1, Alex R. Cook2, Hanley J. Ho2, Mar Soe Win, Ai Leng Khoo, Joshua G.X. Wong, Chun Kiat Lee, Benedict Yan, Roland Jureen, Siew Seen Ho, David C. Lye, Paul A. Tambyah, Yee Sin Leo, Dale Fisher, Jolene Oon, Natasha Bagdasarian, Angela Chow3, Nares Smitasin3, and Louis Yi Ann Chai3Comments to Author 
Author affiliations: National University Health System, Singapore (G. Yan, L. Pang, A.R. Cook, M.S. Win, S.S. Ho, P.A. Tambyah, D. Fisher, J. Oon, N. Bagdasarian, N. Smitasin, L.Y.A. Chai); National University of Singapore (L. Pang, A.R. Cook, P.A. Tambyah, D. Fisher, N. Bagdasarian, L.Y.A. Chai); Tan Tock Seng Hospital, Singapore (H.J. Ho, J.G.X. Wong, D.C. Lye, Y.S. Leo, A. Chow); National University Cancer Institute, Singapore (M.S. Win, L.Y.A. Chai); National Healthcare Group, Singapore (A.L. Khoo); National University Hospital, Singapore (C.K. Lee, B. Yan, R. Jureen)

Main Article

Figure 1

Univariate logistic regression model of clinical characteristics for patients in study of clinical assessments to distinguish Zika and dengue virus infections, Singapore. We analyzed early presentation (seeking treatment within 3 days of symptom onset), conjunctivitis, fever, myalgia, and headache as dichotomous variables, and laboratory findings (monocyte and platelet counts, ALT and AST levels) as continuous variables. For dichotomous variables, odds ratio (OR) >1 is predictive of Zika viru

Figure 1. Univariate logistic regression model of clinical characteristics for patients in study of clinical assessments to distinguish Zika and dengue virus infections, Singapore. We analyzed early presentation (seeking treatment within 3 days of symptom onset), conjunctivitis, fever, myalgia, and headache as dichotomous variables, and laboratory findings (monocyte and platelet counts, ALT and AST levels) as continuous variables. For dichotomous variables, odds ratio (OR) >1 is predictive of Zika virus infection and <1 of dengue virus infection; for continuous variables, every unit increase in readout is predictive of Zika virus infection for OR >1 and dengue virus infection for OR <1. Error bars indicate 95% CIs. ALT, alanine aminotransferase; AST, aspartate aminotransferase.

Main Article

1These authors contributed equally to this article.

2These authors contributed equally to this article.

3These authors contributed equally to this article.

Page created: July 18, 2018
Page updated: July 18, 2018
Page reviewed: July 18, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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