TY - JOUR AU - Rajapakse, Nipunie AU - Ellsworth, Kevin AU - Liesman, Rachael AU - Ho, Mai Lan AU - Henry, Nancy AU - Theel, Elitza AU - Wallace, Adam AU - Alvino, Ana Catarina Ishigami AU - Medeiros de Mello, Luisa AU - Meneses, Jucille T1 - Unilateral Phrenic Nerve Palsy in Infants with Congenital Zika Syndrome T2 - Emerging Infectious Disease journal PY - 2018 VL - 24 IS - 8 SP - 1422 SN - 1080-6059 AB - Since the first identification of neonatal microcephaly cases associated with congenital Zika virus infection in Brazil in 2015, a distinctive constellation of clinical features of congenital Zika syndrome has been described. Fetal brain disruption sequence is hypothesized to underlie the devastating effects of the virus on the central nervous system. However, little is known about the effects of congenital Zika virus infection on the peripheral nervous system. We describe a series of 4 cases of right unilateral diaphragmatic paralysis in infants with congenital Zika syndrome suggesting peripheral nervous system involvement and Zika virus as a unique congenital infectious cause of this finding. All the patients described also had arthrogryposis (including talipes equinovarus) and died from complications related to progressive respiratory failure. KW - Zika virus KW - peripheral nervous system KW - fetal diseases KW - phrenic nerve KW - viruses KW - congenital Zika syndrome KW - phrenic nerve palsy DO - 10.3201/eid2408.180057 UR - https://wwwnc.cdc.gov/eid/article/24/8/18-0057_article ER - End of Reference