TY - JOUR AU - Beyrouthy, Racha AU - Barets, Marion AU - Marion, Elodie AU - Dananché, Cédric AU - Dauwalder, Olivier AU - Robin, Frédéric AU - Gauthier, Lauraine AU - Jousset, Agnès AU - Dortet, Laurent AU - Guérin, François AU - Bénet, Thomas AU - Cassier, Pierre AU - Vanhems, Philippe AU - Bonnet, Richard T1 - Novel Enterobacter Lineage as Leading Cause of Nosocomial Outbreak Involving Carbapenemase-Producing Strains T2 - Emerging Infectious Disease journal PY - 2018 VL - 24 IS - 8 SP - 1505 SN - 1080-6059 AB - We investigated unusual carbapenemase-producing Enterobacter cloacae complex isolates (n = 8) in the novel sequence type (ST) 873, which caused nosocomial infections in 2 hospitals in France. Whole-genome sequence typing showed the 1-year persistence of the epidemic strain, which harbored a blaVIM-4 ST1-IncHI2 plasmid, in 1 health institution and 2 closely related strains harboring blaCTX-M-15 in the other. These isolates formed a new subgroup in the E. hormaechei metacluster, according to their hsp60 sequences and phylogenomic analysis. The average nucleotide identities, specific biochemical properties, and pangenomic and functional investigations of isolates suggested isolates of a novel species that had acquired genes associated with adhesion and mobility. The emergence of this novel Enterobacter phylogenetic lineage within hospitals should be closely monitored because of its ability to persist and spread. KW - Carbapenemase KW - Enterobacter cloacae complex KW - Enterobacteriaceae KW - b-lactamase KW - nosocomial outbreak KW - VIM-4 KW - next-generation sequencing KW - beta-lactamase KW - bacteria KW - antimicrobial resistance KW - carbapenemase-producing Enterobacteriaceae KW - CPE DO - 10.3201/eid2408.180151 UR - https://wwwnc.cdc.gov/eid/article/24/8/18-0151_article ER - End of Reference