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Volume 24, Number 9—September 2018
Dispatch

Association of Batai Virus Infection and Encephalitis in Harbor Seals, Germany, 2016

Wendy K. Jo1, Vanessa M. Pfankuche1, Annika Lehmbecker, Byron Martina, Ana Rubio-Garcia, Stefanie Becker, Jochen Kruppa, Klaus Jung, Daniela Klotz, Julia Metzger, Martin Ludlow, Wolfgang Baumgärtner, Erhard van der Vries2, and Albert OsterhausComments to Author 
Author affiliations: University of Veterinary Medicine Hannover, Hannover, Germany (W.K. Jo, V.M. Pfankuche, A. Lehmbecker, S. Becker, J. Kruppa, K. Jung, D. Klotz, J. Metzger, M. Ludlow, W. Baumgärtner, E. van der Vries, A. Osterhaus); Center for Systems Neuroscience, Hannover (W.K. Jo, V.M. Pfankuche, W. Baumgärtner, A. Osterhaus); Artemis One Health, Delft, the Netherlands (B. Martina, A. Osterhaus); Seal Centre, Pieterburen, the Netherlands (A. Rubio-Garcia)

Main Article

Table

Analysis of a Batai virus–infected harbor seal with meningoencephalomyelitis, Germany, 2016*

Sample material Histopathologic finding Real-time PCR (cycle threshold)† FISH
Brain
 Cerebrum, cerebellum, brain stem, medulla oblongata, and cervical spinal cord: mild to moderate, multifocal, and lymphohistiocytic meningoencephalomyelitis, perivascularly accentuated; parietal lobe: multiple glial nodules; thoracic spinal cord: mild to moderate and multifocal meningitis, perivascularly accentuated, lymphohistiocytic with few eosinophilic granulocytes; cauda equina: mild to moderate, multifocal, and lymphohistiocytic perineuritis
 + (15)
 +
Lung
 Mild and multifocal anthracosis; acute, diffuse, and severe hyperemia; acute, diffuse, and moderate edema
 – (>35)
 –
Spleen
 Moderate to severe and diffuse hyperemia
 – (35)
 –
Kidney
 Mild, interstitial, and lymphohistiocytic nephritis with single, intratubular concrements
 – (>35)
 –
Pulmonary lymph node
 Mild follicular hyperplasia
 NI
 ­+
Mesenteric lymph node
 Mild to moderate follicular hyperplasia and hemosiderosis
 NI
 –
Liver
 Mild, multifocal, lymphohistiocytichepatitis, mild to moderate hepatocellular storage of iron
 – (>35)
 –
Small intestine
 Mild, diffuse, lymphoplasmacytic, and partially eosinophilic enteritis
 + (28)
 +
Large intestine
 NSML
 NI
 –
Nose
 NSML
 NI
 –
Heart
 NSML
 NI
 –
Stomach NSML NI –

*FISH, fluorescent in situ hybridization; NI, not investigated; NSML, no major microscopic lesions; –, negative; +, positive.
†Negative result >35; positive result <35.

Main Article

1These authors contributed equally to this article.

2Current affiliation: Utrecht University, Utrecht, the Netherlands.

Page created: August 15, 2018
Page updated: August 15, 2018
Page reviewed: August 15, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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