Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential
Joshua E. Sealy, Tahir Yaqub, Thomas P. Peacock1
, Pengxiang Chang, Burcu Ermetal, Anabel Clements, Jean-Remy Sadeyen, Arslan Mehboob2
, Holly Shelton, Juliet E. Bryant, Rod S. Daniels, John W. McCauley, Munir Iqbal
, and Jean-Remy Royal Veterinary CollegeLondonUKSadeyen
Author affiliations: The Pirbright Institute, Pirbright, UK (J.E. Sealy, T.P. Peacock, P. Chang, A. Clements, J.-R. Sadeyen, H. Shelton, M. Iqbal); University of Veterinary and Animal Sciences, Lahore, Pakistan (T. Yaqub, A. Mehboob); The Francis Crick Institute, London (B. Ermetal, R.S. Daniels, J.W. McCauley); Fondation Mérieux, Lyon, France (J.E. Bryant)
Figure 5. Elution of influenza A(H9N2) viruses (UDL-01/08 and SKP-827/16 A/T/V180) from Pakistan from erythrocytes. Virus elution was recorded at 1, 2, 3, 4, 5, 6, and 24 hours posttreatment with bacterial receptor-destroying enzyme. Points plotted indicate hour at which full loss of hemagglutination was achieved for each concentration of receptor-destroying enzyme. A) Canine erythrocyte elution with UDL and 827 A/T/V180; B) chicken erythrocyte elution with UDL and 827 A/T/V180; C) guinea pig erythrocyte elution with UDL and 827 A/T/V180. mgP, milligram of protein.
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