Volume 25, Number 1—January 2019
Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential
|HA backbone and substitution
||Fold change in MNT titer (titer)†
*MNT assays were conducted by using antiserum raised against UDL-01/08 as before and RG viruses at 100 50% tissue culture infectious doses. Wild-type virus UDL-01/08 was compared to UDL-01/08 HA backbone variants with A180T and A180V substitutions, and wild-type virus SKP-827/16 was compared with SKP-827/16 HA backbone variants with T180A and T180V substitutions. HA, hemagglutinin; MNT, microneutralization.
†The homologous MNT titer for UDL-01/08 antiserum was 256.
‡Value indicates fold increase,
§Values indicate fold decrease.
1Current affiliation: Imperial College London, London, UK.
2Current affiliation: Chinese Academy of Agricultural Sciences, Beijing, China.