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Volume 25, Number 1—January 2019

Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential

Joshua E. Sealy, Tahir Yaqub, Thomas P. Peacock1, Pengxiang Chang, Burcu Ermetal, Anabel Clements, Jean-Remy Sadeyen, Arslan Mehboob2, Holly Shelton, Juliet E. Bryant, Rod S. Daniels, John W. McCauley, Munir IqbalComments to Author , and Jean-Remy Royal Veterinary CollegeLondonUKSadeyen
Author affiliations: The Pirbright Institute, Pirbright, UK (J.E. Sealy, T.P. Peacock, P. Chang, A. Clements, J.-R. Sadeyen, H. Shelton, M. Iqbal); University of Veterinary and Animal Sciences, Lahore, Pakistan (T. Yaqub, A. Mehboob); The Francis Crick Institute, London (B. Ermetal, R.S. Daniels, J.W. McCauley); Fondation Mérieux, Lyon, France (J.E. Bryant)

Main Article

Table 2

Changes in MNT titers influenza A(H9N2) viruses with HA A/T/V180 substitutions*

HA backbone and substitution
Fold change in MNT titer (titer)†
T180A 4‡ (1,024)
3§ (4)
A180T 3§ (32)
A180V >6§ (2)

*MNT assays were conducted by using antiserum raised against UDL-01/08 as before and RG viruses at 100 50% tissue culture infectious doses. Wild-type virus UDL-01/08 was compared to UDL-01/08 HA backbone variants with A180T and A180V substitutions, and wild-type virus SKP-827/16 was compared with SKP-827/16 HA backbone variants with T180A and T180V substitutions. HA, hemagglutinin; MNT, microneutralization.
†The homologous MNT titer for UDL-01/08 antiserum was 256.
‡Value indicates fold increase,
§Values indicate fold decrease.

Main Article

1Current affiliation: Imperial College London, London, UK.

2Current affiliation: Chinese Academy of Agricultural Sciences, Beijing, China.

Page created: December 18, 2018
Page updated: December 18, 2018
Page reviewed: December 18, 2018
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