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Volume 25, Number 10—October 2019

Comparison of Serologic Assays for Middle East Respiratory Syndrome Coronavirus

Ruth Harvey, Giada MattiuzzoComments to Author , Mark Hassall, Andrea Sieberg, Marcel A. Müller, Christian Drosten, Peter Rigsby, Christopher J. Oxenford, and study participants
Author affiliations: National Institute for Biological Standards and Control—MHRA, Potters Bar, UK (R. Harvey, G. Mattiuzzo, M. Hassall, P. Rigsby); Charité-Universitätsmedizin Berlin, Berlin, Germany (A. Sieberg, M.A. Müller, C. Drosten); German Centre for Infection Research, Berlin (M.A. Müller, C. Drosten); World Health Organization, Lyon, France (C.J. Oxenford).

Main Article

Table 2

Characterization of MERS-CoV–negative control serum panel included in study of serologic assays for MERS-CoV*

Name Recombinant spike protein–based indirect immunofluorescence test, reciprocal endpoint titers*
WHO/A 160 1,280 320 640 NR NR
WHO/B 2,560 1,280 1,280 160 NR NR
WHO/C 160 320 1,280 320 NR NR
WHO/D 1,280 2,560 320 160 NR NR
WHO/E 320 1,280 160 160 NR NR
WHO/F 80 320 320 160 NR NR
WHO/G 320 320 1,280 1,280 NR NR

*All serum samples were tested in a dilution range of 1:20 to 1:5,120. CoV, coronavirus; HCoV, human CoV; MERS, Middle East respiratory syndrome; NR, nonreactive at the cutoff serum dilution of 1:20; SARS, severe acute respiratory syndrome; WHO, World Health Organization.

Main Article

1Study participants who contributed data are listed at the end of this article.

Page created: September 17, 2019
Page updated: September 17, 2019
Page reviewed: September 17, 2019
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