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Volume 25, Number 10—October 2019
Research

Comparison of Serologic Assays for Middle East Respiratory Syndrome Coronavirus

Ruth Harvey, Giada MattiuzzoComments to Author , Mark Hassall, Andrea Sieberg, Marcel A. Müller, Christian Drosten, Peter Rigsby, Christopher J. Oxenford, and study participants
Author affiliations: National Institute for Biological Standards and Control—MHRA, Potters Bar, UK (R. Harvey, G. Mattiuzzo, M. Hassall, P. Rigsby); Charité-Universitätsmedizin Berlin, Berlin, Germany (A. Sieberg, M.A. Müller, C. Drosten); German Centre for Infection Research, Berlin (M.A. Müller, C. Drosten); World Health Organization, Lyon, France (C.J. Oxenford).

Main Article

Table 2

Characterization of MERS-CoV–negative control serum panel included in study of serologic assays for MERS-CoV*

Name Recombinant spike protein–based indirect immunofluorescence test, reciprocal endpoint titers*
HCoV-229E HCoV-NL63 HCoV-OC43 HCoV-HKU1 SARS-CoV MERS-CoV
WHO/A 160 1,280 320 640 NR NR
WHO/B 2,560 1,280 1,280 160 NR NR
WHO/C 160 320 1,280 320 NR NR
WHO/D 1,280 2,560 320 160 NR NR
WHO/E 320 1,280 160 160 NR NR
WHO/F 80 320 320 160 NR NR
WHO/G 320 320 1,280 1,280 NR NR

*All serum samples were tested in a dilution range of 1:20 to 1:5,120. CoV, coronavirus; HCoV, human CoV; MERS, Middle East respiratory syndrome; NR, nonreactive at the cutoff serum dilution of 1:20; SARS, severe acute respiratory syndrome; WHO, World Health Organization.

Main Article

1Study participants who contributed data are listed at the end of this article.

Page created: September 17, 2019
Page updated: September 17, 2019
Page reviewed: September 17, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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