TY - JOUR AU - French, Nigel AU - Zhang, Ji AU - Carter, Glen AU - Midwinter, Anne AU - Biggs, Patrick AU - Dyet, Kristin AU - Gilpin, Brent AU - Ingle, Danielle AU - Mulqueen, Kerry AU - Rogers, Lynn AU - Wilkinson, David AU - Greening, Sabrina AU - Muellner, Petra AU - Fayaz, Ahmed AU - Williamson, Deborah T1 - Genomic Analysis of Fluoroquinolone- and Tetracycline-Resistant Campylobacter jejuni Sequence Type 6964 in Humans and Poultry, New Zealand, 2014–2016 T2 - Emerging Infectious Disease journal PY - 2019 VL - 25 IS - 12 SP - 2226 SN - 1080-6059 AB - In 2014, antimicrobial drug–resistant Campylobacter jejuni sequence type 6964 emerged contemporaneously in poultry from 3 supply companies in the North Island of New Zealand and as a major cause of campylobacteriosis in humans in New Zealand. This lineage, not previously identified in New Zealand, was resistant to tetracycline and fluoroquinolones. Genomic analysis revealed divergence into 2 major clades; both clades were associated with human infection, 1 with poultry companies A and B and the other with company C. Accessory genome evolution was associated with a plasmid, phage insertions, and natural transformation. We hypothesize that the tetO gene and a phage were inserted into the chromosome after conjugation, leaving a remnant plasmid that was lost from isolates from company C. The emergence and rapid spread of a resistant clone of C. jejuni in New Zealand, coupled with evolutionary change in the accessory genome, demonstrate the need for ongoing Campylobacter surveillance among poultry and humans. KW - Campylobacter jejuni KW - antimicrobial resistance KW - poultry KW - plasmid KW - tetracycline KW - fluoroquinolone KW - bacteria KW - New Zealand DO - 10.3201/eid2512.190267 UR - https://wwwnc.cdc.gov/eid/article/25/12/19-0267_article ER - End of Reference