TY - JOUR AU - Griffin, Isabel AU - Martin, Stacey AU - Fischer, Marc AU - Chambers, Trudy AU - Kosoy, Olga AU - Falise, Alyssa AU - Ponomareva, Olga AU - Gillis, Leah AU - Blackmore, Carina AU - Jean, Reynald T1 - Zika Virus IgM Detection and Neutralizing Antibody Profiles 12–19 Months after Illness Onset T2 - Emerging Infectious Disease journal PY - 2019 VL - 25 IS - 2 SP - 299 SN - 1080-6059 AB - Data on the duration of detectable Zika virus–specific IgM in infected persons are limited. Neutralizing antibody cross-reactivity occurs between Zika virus and related flaviviruses, but the degree to which this confounds diagnosis is uncertain. We tested serum specimens collected 12–19 months after illness onset from patients with confirmed Zika virus disease for Zika virus IgM and Zika virus and dengue virus neutralizing antibodies. Among 62 participants, 45 (73%) had detectable Zika virus IgM and 12 (19%) had an equivocal result. Although all patients tested had Zika virus neutralizing antibodies, 39 (63%) also had neutralizing antibodies against dengue virus; of those, 12 (19%) had <4-fold difference between Zika virus and dengue virus titers, and 5 (8%) had dengue virus titer >4-fold higher than Zika virus titer. Prolonged detection of IgM and neutralizing antibody cross-reactivity make it difficult to determine the timing of Zika virus infection and differentiate between related flaviviruses. KW - Zika virus KW - immunoglobulin KW - IgM KW - MAC-ELISA KW - flaviviruses KW - neutralizing antibodies KW - viruses KW - Florida KW - United States DO - 10.3201/eid2502.181286 UR - https://wwwnc.cdc.gov/eid/article/25/2/18-1286_article ER - End of Reference