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Volume 25, Number 2—February 2019
Research

Macrophage Activation Marker Soluble CD163 Associated with Fatal and Severe Ebola Virus Disease in Humans1

Anita K. McElroyComments to Author , Punya Shrivastava-Ranjan, Jessica R. Harmon, Roosecelis B. Martines, Luciana Silva-Flannery, Timothy D. Flietstra, Colleen S. Kraft, Aneesh K. Mehta, G. Marshall Lyon, Jay B. Varkey, Bruce S. Ribner, Stuart T. Nichol, Sherif R. Zaki, and Christina F. Spiropoulou
Author affiliations: University of Pittsburgh, Pittsburgh, Pennsylvania, USA (A.K. McElroy); Centers for Disease Control and Prevention, Atlanta (A.K. McElroy, P. Shrivastava-Ranjan, J.R. Harmon, R.B. Martines, L Silva-Flannery, T.D. Flietstra, S.T. Nichol, S.R. Zaki, C.F. Spiropoulou); Emory University School of Medicine, Atlanta, Georgia, USA (A.K. McElroy, C.S. Kraft, A.K. Mehta, G.M. Lyon, J.B. Varkey, B.S. Ribner)

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Figure 2

Immunohistochemical stains of tissue from patients with fatal cases of Ebola virus (EBOV) disease showing EBOV (red) and CD163 (brown) antigens. A) Hematoxylin and eosin stain of liver showing hepatocellular necrosis with intracytoplasmic eosinophilic inclusions (arrow). B) EBOV antigens in hepatocytes and CD163 antigens in macrophages. C) High magnification image of double immunohistochemical staining of liver tissue showing colocalization of EBOV and CD163 antigens in macrophage (arrow). D) Co

Figure 2. Immunohistochemical stains of tissue from patients with fatal cases of Ebola virus (EBOV) disease showing EBOV (red) and CD163 (brown) antigens. A) Hematoxylin and eosin stain of liver showing hepatocellular necrosis with intracytoplasmic eosinophilic inclusions (arrow). B) EBOV antigens in hepatocytes and CD163 antigens in macrophages. C) High magnification image of double immunohistochemical staining of liver tissue showing colocalization of EBOV and CD163 antigens in macrophage (arrow). D) Colocalization of EBOV and CD163 antigen in macrophage of spleen (arrow). E) Staining of EBOV and interstitial macrophages (CD163) in heart. EBOV found in some cardiomyocytes. F) EBOV and CD163 antigen in endothelial cells (arrowhead) and macrophages of testis (arrow). Original magnification ×20 (A, B, D, E, F); ×63 (C).

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1Preliminary results from this study were presented at the American Association of Immunology annual meeting, May 4-8, 2018, Austin, Texas, USA.

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Page updated: January 16, 2019
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