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Volume 25, Number 3—March 2019
Dispatch

Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012–2016

Imen BouzouitaComments to Author , Andrea Maurizio Cabibbe, Alberto Trovato, Henda Daroui, Asma Ghariani, Basma Midouni, Leila Essalah, Emna Mehiri, Daniela Maria Cirillo, and Leila Slim Saidi
Author affiliations: National Reference Laboratory for Mycobacteria, Ariana, Tunisia (I. Bouzouita, H. Daroui, A. Ghariani, B. Midouni, L. Essalah, E. Mehiri, L. Slim Saidi); University of Tunis El Manar, Tunis, Tunisia (I. Bouzouita, B. Midouni); San Raffaele Scientific Institute, Milan, Italy (A.M. Cabibbe, A. Trovato, D.M. Cirillo); University of Monastir, Monastir, Tunisia (A. Ghariani, E. Mehiri, L. Slim Saidi)

Main Article

Table 1

Epidemiologic information about clustered cases identified during study of drug-resistant Mycobacterium tuberculosis strains, Tunisia, 2012–2016*

Cluster, group pncA mutation No. patients Epidemiologic links
Cluster 1, Haarlem†
Group 1 Gln10His 9 Confirmed for patients 10942, 14666 (2 brothers with XDR TB), 
8626 (their neighbor with XDR TB) in Bizerte, and patients 
13025 and 2109 (2 friends from Bizerte); probable for patients 
3553, 436, 5069, 8649 (from Bizerte)
Group 2 Leu4Trp 5 Probable for patients 18013 and 2666 (from Sousse, 
the central part of Tunisia)
Group 3 A-11C 4 Not available
Group 4 CA deletion (+339, +340) 2 Probable for patients 11356 and 15359 (from Ben Arous, 10 km from the capital Tunis)
Group 5 Cys14Stop 2 Confirmed for patients 1914 and 14512 (brother and sister from Bizerte)
Group 6
 Wild type
 2
 Not available
Cluster 2, Haarlem
 Wild type
 3
 Confirmed for patients 13138, 18959, 16653 (same family: father, son, and uncle; Beja; Northwest of Tunisia)
Cluster 3, LAM Wild type 3 Confirmed for patients 10101, 11419, 6840 (neighbors from Ben Arous)

*LAM, Latin-American-Mediterranean.
†For the remaining patients of cluster 1, no information was available.

Main Article

Page created: February 19, 2019
Page updated: February 19, 2019
Page reviewed: February 19, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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