Volume 25, Number 6—June 2019
CME ACTIVITY - Synopsis
Epidemiologic and Clinical Features of Lassa Fever Outbreak in Nigeria, January 1–May 6, 2018
Table 1
State or territory | Population, ×1,000* | No. confirmed cases (deaths) | Case-fatality rate, % | No. confirmed cases/100,000 population | No. laboratory-negative suspected cases | No. probable cases | Positive rate, % |
---|---|---|---|---|---|---|---|
Abia | 3,727 | 1 (1) | 100.0 | 0.027 | 11 | 1 | 8.3 |
Adamawa | 4,248 | 1 (1) | 100.0 | 0.024 | 2 | 1 | 33.3 |
Anambra | 5,528 | 4 (2) | 50.0 | 0.072 | 3 | 0 | 57.1 |
Bauchi | 6,537 | 10 (5) | 50.0 | 0.153 | 50 | 0 | 16.7 |
Benue | 5,742 | 1 (1) | 100.0 | 0.017 | 6 | 1 | 14.3 |
Delta | 5,663 | 7 (3) | 42.9 | 0.124 | 3 | 0 | 70.0 |
Ebonyi | 2,880 | 64 (15) | 23.4 | 2.222 | 28 | 4 | 69.6 |
Edo | 4,236 | 178 (26) | 14.6 | 4.202 | 901 | 0 | 16.5 |
Ekiti | 3,271 | 2 (1) | 50.0 | 0.061 | 10 | 0 | 16.7 |
Federal Capital Territory | 3,564 | 3 (2) | 66.7 | 0.084 | 38 | 0 | 7.3 |
Gombe | 3,257 | 2 (2) | 100.0 | 0.061 | 13 | 0 | 13.3 |
Imo | 5,409 | 4 (1) | 25.0 | 0.074 | 11 | 0 | 26.7 |
Kaduna | 8,252 | 1 (1) | 100.0 | 0.012 | 4 | 0 | 20.0 |
Kogi | 4,474 | 11 (4) | 36.4 | 0.246 | 15 | 2 | 42.3 |
Lagos | 12,551 | 1 (1) | 100.0 | 0.008 | 28 | 0 | 3.4 |
Nasarawa | 2,523 | 3 (2) | 66.7 | 0.119 | 34 | 0 | 8.1 |
Ondo | 4,672 | 99 (24) | 24.2 | 2.119 | 214 | 1 | 31.6 |
Osun | 4,706 | 2 (1) | 50.0 | 0.043 | 2 | 0 | 50.0 |
Plateau | 4,200 | 9 (7) | 77.8 | 0.214 | 39 | 0 | 18.8 |
Rivers | 7,304 | 1 (1) | 100.0 | 0.014 | 7 | 0 | 12.5 |
Taraba |
3,067 |
19 (5) |
26.3 |
0.620 |
41 |
0 |
31.7 |
Total | 193,393 | 423 (106) | 25.1 | 0.219 | 1,460 | 10 | 22.5 |
*Data source: National Bureau of Statistics (22).
References
- Frame JD, Baldwin JM Jr, Gocke DJ, Troup JM. Lassa fever, a new virus disease of man from West Africa. I. Clinical description and pathological findings. Am J Trop Med Hyg. 1970;19:670–6. DOIPubMedGoogle Scholar
- Monath TP, Newhouse VF, Kemp GE, Setzer HW, Cacciapuoti A. Lassa virus isolation from Mastomys natalensis rodents during an epidemic in Sierra Leone. Science. 1974;185:263–5. DOIPubMedGoogle Scholar
- Richmond JK, Baglole DJ. Lassa fever: epidemiology, clinical features, and social consequences. BMJ. 2003;327:1271–5. DOIPubMedGoogle Scholar
- Keenlyside RA, McCormick JB, Webb PA, Smith E, Elliott L, Johnson KM. Case-control study of Mastomys natalensis and humans in Lassa virus-infected households in Sierra Leone. Am J Trop Med Hyg. 1983;32:829–37. DOIPubMedGoogle Scholar
- Fisher-Hoch SP, Tomori O, Nasidi A, Perez-Oronoz GI, Fakile Y, Hutwagner L, et al. Review of cases of nosocomial Lassa fever in Nigeria: the high price of poor medical practice. BMJ. 1995;311:857–9. DOIPubMedGoogle Scholar
- Ajayi NA, Nwigwe CG, Azuogu BN, Onyire BN, Nwonwu EU, Ogbonnaya LU, et al. Containing a Lassa fever epidemic in a resource-limited setting: outbreak description and lessons learned from Abakaliki, Nigeria (January-March 2012). Int J Infect Dis. 2013;17:e1011–6. DOIPubMedGoogle Scholar
- World Health Organization. Lassa fever fact sheet [cited 2018 May 13]. http://origin.who.int/mediacentre/factsheets/fs179
- Centers for Disease Control and Prevention. Lassa fever [cited 2018 May 13]. http://www.cdc.gov/vhf/lassa
- Nigeria Centre for Disease Control. Standard operating procedures for Lassa fever case management [cited 2018 May 13]. http://www.ncdc.gov.ng/themes/common/docs/protocols/30_1502277315.pdf
- Nigeria Centre for Disease Control. Honourable Minister of Health announces end of emergency phase of Nigeria’s Lassa fever outbreak [cited 2018 May 13]. http://ncdc.gov.ng/news/142/honourable-minister-of-health-announces-end-of-emergency-phase-of-nigeria%5C%27s-lassa-fever-outbreak
- McCormick JB, King IJ, Webb PA, Scribner CL, Craven RB, Johnson KM, et al. Lassa fever. Effective therapy with ribavirin. N Engl J Med. 1986;314:20–6. DOIPubMedGoogle Scholar
- Stephenson EH, Larson EW, Dominik JW. Effect of environmental factors on aerosol-induced Lassa virus infection. J Med Virol. 1984;14:295–303. DOIPubMedGoogle Scholar
- Fichet-Calvet E, Lecompte E, Koivogui L, Soropogui B, Doré A, Kourouma F, et al. Fluctuation of abundance and Lassa virus prevalence in Mastomys natalensis in Guinea, West Africa. Vector Borne Zoonotic Dis. 2007;7:119–28. DOIPubMedGoogle Scholar
- Nigeria Centre for Disease Control. Weekly Epidemiological Report. Weekly updates on epidemics in Nigeria: as at 16th September, 2016 [cited 2018 May 13]. http://www.ncdc.gov.ng/reports/7/2016-september-week-37
- Nigeria Centre for Disease Control. Weekly Epidemiological Report. Weekly updates on epidemics in Nigeria: as at 6th January, 2016 [cited 2018 May 13]. http://www.ncdc.gov.ng/reports/23/2017-january-week-1
- Nigeria Centre for Disease Control. Weekly Epidemiological Report. Stopping spread of Lassa fever: instituting infection prevention control measures in health facilities [cited 2018 May 13]. http://www.ncdc.gov.ng/reports/104/2018-january-week-3
- Nigeria Centre for Disease Control. An update of Lassa fever outbreak in Nigeria for week 19 [cited 2018 May 13]. http://www.ncdc.gov.ng/themes/common/files/sitreps/473e68581953ff7e0d0b08445c1f6726.pdf
- Otto JL, Holodniy M, DeFraites RF. Public health practice is not research. Am J Public Health. 2014;104:596–602. DOIPubMedGoogle Scholar
- Nikisins S, Rieger T, Patel P, Müller R, Günther S, Niedrig M. International external quality assessment study for molecular detection of Lassa virus. PLoS Negl Trop Dis. 2015;9:
e0003793 . DOIPubMedGoogle Scholar - Andersen KG, Shapiro BJ, Matranga CB, Sealfon R, Lin AE, Moses LM, et al.; Viral Hemorrhagic Fever Consortium. Clinical sequencing uncovers origins and evolution of Lassa virus. Cell. 2015;162:738–50. DOIPubMedGoogle Scholar
- Isere EE, Fatiregun AA, Ajayi IO. An overview of disease surveillance and notification system in Nigeria and the roles of clinicians in disease outbreak prevention and control. Niger Med J. 2015;56:161–8. DOIPubMedGoogle Scholar
- National Bureau of Statistics. National population estimates [cited 2018 May 19] https://nigerianstat.gov.ng/download/474
- Yalley-Ogunro JE, Frame JD, Hanson AP. Endemic Lassa fever in Liberia. VI. Village serological surveys for evidence of Lassa virus activity in Lofa County, Liberia. Trans R Soc Trop Med Hyg. 1984;78:764–70. DOIPubMedGoogle Scholar
- Bausch DG, Demby AH, Coulibaly M, Kanu J, Goba A, Bah A, et al.; Epidemiology of Human Disease and Clinical Observations. Lassa fever in Guinea: I. Epidemiology of human disease and clinical observations. Vector Borne Zoonotic Dis. 2001;1:269–81. DOIPubMedGoogle Scholar
- Fraser DW, Campbell CC, Monath TP, Goff PA, Gregg MB. Lassa fever in the Eastern province of Sierra Leone, 1970–1972. I. Epidemiologic studies. Am J Trop Med Hyg. 1974;23:1131–9. DOIPubMedGoogle Scholar
- Yinka-Ogunleye A, Ipadeola O, Saleh M, Ilori E, Dan-Nwafor C, Nwachukwu W, et al. 2016/2017 Lassa fever outbreak in Nigeria: age and sex have no effect on treatment outcome. Pan Afr Med J. 2018;8:3.
- McCormick JB, King IJ, Webb PA, Johnson KM, O’Sullivan R, Smith ES, et al. A case-control study of the clinical diagnosis and course of Lassa fever. J Infect Dis. 1987;155:445–55. DOIPubMedGoogle Scholar
- Okokhere P, Colubri A, Azubike C, Iruolagbe C, Osazuwa O, Tabrizi S, et al. Clinical and laboratory predictors of Lassa fever outcome in a dedicated treatment facility in Nigeria: a retrospective, observational cohort study. Lancet Infect Dis. 2018;18:684–95. DOIPubMedGoogle Scholar
- McCormick JB. Clinical, epidemiologic, and therapeutic aspects of Lassa fever. Med Microbiol Immunol (Berl). 1986;175:153–5. DOIPubMedGoogle Scholar
- Lo Iacono G, Cunningham AA, Fichet-Calvet E, Garry RF, Grant DS, Khan SH, et al. Using modelling to disentangle the relative contributions of zoonotic and anthroponotic transmission: the case of lassa fever. PLoS Negl Trop Dis. 2015;9:
e3398 . DOIPubMedGoogle Scholar - Siddle KJ, Eromon P, Barnes KG, Mehta S, Oguzie JU, Odia I, et al. Genomic analysis of Lassa virus during an increase in cases in Nigeria in 2018. N Engl J Med. 2018;379:1745–53. DOIPubMedGoogle Scholar
1These first authors contributed equally to this article.
2Other members of the Nigeria Lassa Fever National Response Team are listed at the end of this article.
Page created: May 19, 2019
Page updated: May 19, 2019
Page reviewed: May 19, 2019
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