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Volume 25, Number 6—June 2019

Use of Single-Injection Recombinant Vesicular Stomatitis Virus Vaccine to Protect Nonhuman Primates Against Lethal Nipah Virus Disease

Chad E. Mire, Joan B. Geisbert, Krystle N. Agans, Krista M. Versteeg, Daniel J. Deer, Benjamin A. Satterfield1, Karla A. Fenton, and Thomas W. GeisbertComments to Author 
Author affiliations: Galveston National Laboratory, Galveston, Texas, USA; University of Texas Medical Branch, Galveston

Main Article

Table 2

Clinical findings and outcome of Nipah virus Bangladesh strain–challenged African green monkeys*

Animal no. Sex Group Clinical illness Clinical and gross pathology findings†
Control ΔG vaccine
Loss of appetite (d 6–8); labored breathing (d 6–8). Died on d 8.
Lymphopenia (d 6); serosanguinous nasal and oral discharge (d 8), serosanguinous pleural fluid, severely inflated, enlarged lungs with severe congestion and hemorrhage of all lobes, multifocal to coalescing hemorrhage of the mucosal surface of the urinary bladder.
F-1 F F vaccine None Thrombocytopenia (d 15); >3 fold increase in ALT (d 6), >3 fold increase in AST
F-2 M F vaccine None None
F vaccine
Increase in CRP (d 6)
G-1 F G vaccine None None
G-2 M G vaccine None None
G vaccine
F/G-1 F F + G vaccine None Increase in CRP (d 8)
F/G-2 M F + G vaccine None Thrombocytopenia (d 21, d 28); increase in CRP (d 8, d 10, d 15)
F/G-3 M F + G vaccine None Thrombocytopenia (d 8)

*ALT, alanine aminotransferase; AST, aspartate aminotransferase; CRP, C-reactive protein.
†Lymphopenia is defined as a >30% decrease in number of lymphocytes; thrombocytopenia is defined as a >30% decrease in number of platelets.

Main Article

1Current affiliation: Mayo Clinic, Rochester, Minnesota, USA.

Page created: May 20, 2019
Page updated: May 20, 2019
Page reviewed: May 20, 2019
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