Volume 25, Number 7—July 2019
CME ACTIVITY - Research
Hospital-Associated Multicenter Outbreak of Emerging Fungus Candida auris, Colombia, 2016
Table 3
Characteristics of patients who died at 30 d compared with those who survived Candida auris bloodstream infection, Colombia, 2015–2016*
Characteristic | Total | Died | Survived | Crude odds ratio (95% CI) | p value† |
---|---|---|---|---|---|
All |
40 (100) |
17 (43) |
23 (58) |
NA |
NA |
Age, y | 0.18 | ||||
<1 | 12 (30) | 5 (29) | 7 (30) | 0.95 (0.24–3.75) | 0.94 |
1–17 | 8 (20) | 2 (12) | 6 (26) | 0.24 (0.04–1.45) | 0.12 |
18–65 | 14 35) | 5 (29) | 9 (39) | 0.65 (0.17–2.47) | 0.53 |
>65 |
6 (15) |
5 (29) |
1 (4) |
9.17 (0.96–87.79) |
0.05 |
Sex | 0.92 (0.26–3.30) | 0.9 | |||
M | 24 (60) | 10 (59) | 14 (61) | ||
F |
16 (40) |
7 (41) |
9 (39) |
||
Concurrent conditions | 35 (88) | 16 (94) | 19 (83) | 3.37 (0.34–33.26) | 0.30 |
Chronic renal disease | 9 (23) | 3 (18) | 6 (26) | 0.61 (0.13–2.88) | 0.53 |
Hemodialysis dependent | 9 (23) | 3 (18) | 6 (26) | 0.61 (0.13–2.88) | 0.53 |
Diabetes | 7 (18) | 6 (35) | 1 (4) | 12 (1.28–112.42) | 0.03 |
Immunosuppressive condition |
6 (16) |
4 (24) |
2 (9) |
3.23 (0.52–20.20) |
0.21 |
Prematurity, n = 12 |
5 (42) |
1 (6) |
4 (17) |
0.30 (0.03–2.93) |
0.30 |
Median length of hospital stay, d (IQR) |
46 (34–69) |
36 (29–45) |
63 (45–95) |
NA |
<0.01 |
Median length of ICU stay, d (IQR) | 36 (25–58) | 32 (27–44) | 51 (14–76) | NA | 0.3 |
Central venous catheter | 40 (100) | 17 (100) | 23(100) | NA | NA |
Respiratory support | 36 (90) | 17 (100) | 19 (83) | NA | 0.12 |
Vasopressors | 31 (82) | 16 (94) | 15 (65) | 8.53 (0.95–76.63) | 0.06 |
Surgical procedure | 28 (70) | 13 (76) | 15 (65) | 1.73 (0.43–7.11) | 0.45 |
Total parenteral nutrition | 19 (50) | 7 (41) | 12 (52) | 0.64 (0.18–2.28) | 0.49 |
Corticosteroids | 18 (47) | 8 (47) | 10 (43) | 1.16 (0.33–4.07) | 0.82 |
Hemodialysis | 15 (38) | 8 (47) | 7 (30) | 2.03 (0.55–7.47) | 0.29 |
Chemotherapy |
4 (11) |
2 (12) |
2 (9) |
1.4 (0.18–11.08) |
0.74 |
Median time from admission to C. auris positive culture, d (IQR) |
22 (18–31) |
22 (21–37) |
21 (12–28) |
NA |
0.23 |
Isolates resistant to fluconazole, n = 34 | 6 (18) | 4 (24) | 2 (9) | 3.23 (0.52–20.2) | 0.21 |
Isolates resistant to amphotericin B, n = 34 | 10 (29) | 4 (24) | 6 (26) | 0.87 (0.20–3.74) | 0.85 |
*Values are no. (%) patients except as indicated. ICU, intensive care unit; IQR, interquartile ratio; NA, not applicable.
†Fisher exact test, χ2, t-test, or Wilcoxon rank as appropriate.
1These authors contributed equally to this article.
2These authors contributed equally to this article.