Volume 25, Number 7—July 2019
Facility-Associated Release of Polioviruses into Communities—Risks for the Posteradication Era
|Year||Location (reference)||Source||Poliovirus type||No. cases*||Exposure
||United States (20,21)
||Bitten (cutaneous disruption) by a normal macaque while doing work on poliomyelitis (paralysis); filterable virus capable of reproducing the disease in rabbits was isolated from the case; case was fatal
||United States (22)
||Vaccine production facility
||Vaccine trial patients, age 5 mo to 20 y
||12 cases of paralytic poliomyelitis in patients receiving trial vaccination against poliomyelitis; natural infections ruled out as cause; 6 deaths
||United States (19,20,23)
||Lab staff member experienced paralysis after preparation of infected tissues for inoculation into monkeys; cutaneous inoculation; no polio outbreaks reported in place of residence or areas of travel
||United States (20,23)
||Lab staff member scratched on hand by noninoculated monkey during transport; subsequent virus contamination of hands might have occurred while feeding or inoculating monkeys; patient experienced paralysis and later died
||Zimbabwe (formerly Rhodesia) (20,25)
||Infection acquired during inoculation of monkeys with polio virus; paralysis occurred, case was fatal
||United States (20,24)
||WPV2 (mouse- adapted Lansing strain)
||Two lab technicians were infected in the eyes and nose with Lansing (Armstrong) strain while inoculating mice during polio experiments; both experienced paralysis
||Doctor acquired poliomyelitis while performing autopsy on poliomyelitis patient; intracutaneous inoculation; residual weakness; case was not fatal
|1954||United Kingdom (20,26)||Lab||WPV2 (MEF-1) strain||1||Lab staff||NA||NA||Lab technicians infected by cutaneous inoculation while performing necropsy on animals infected with wild type-2 (MEF-1) strain; subsequent paralysis; cases were not fatal|
*Cases defined as laboratory positive (with or without paralysis) for poliovirus by standard methods of virus isolation or known exposure to poliovirus. Lab, laboratory; MEF-1, wild poliovirus type 2 laboratory reference strain; NA, not applicable; WPV2, wild poliovirus type 2.
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