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Volume 25, Number 8—August 2019
Research

17DD Yellow Fever Revaccination and Heightened Long-Term Immunity in Populations of Disease-Endemic Areas, Brazil

Ana Carolina Campi-AzevedoComments to Author , Vanessa Peruhype-Magalhāes, Jordana Grazziela Coelho-dos-Reis, Lis Ribeiro Antonelli, Christiane Costa-Pereira, Elaine Speziali, Laise Rodrigues Reis, Jandira Aparecida Lemos, José Geraldo Leite Ribeiro, Luiz Antônio Bastos Camacho, Maria de Lourdes de Sousa Maia, Sheila Maria Barbosa de Lima, Marisol Simões, Reinaldo de Menezes Martins, Akira Homma, Luiz Cosme Cota Malaquias, Pedro Luiz Tauil, Pedro Fernando Costa Vasconcelos, Alessandro Pecego Martins Romano, Carla Magda Domingues, Andréa Teixeira-Carvalho, Olindo Assis Martins-FilhoComments to Author , and Collaborative Group for Studies of Yellow Fever Vaccine
Author affiliations: Instituto René Rachou of Fundação Oswaldo Cruz (FIOCRUZ-Minas),; Belo Horizonte, Brazil (A.C. Campi-Azevedo, V. Peruhype-Magalhāes, J.G. Coelho-dos-Reis, L.R. Antonelli, C. Costa-Pereira, E. Speziali, L.R. Reis, A. Teixeira-Carvalho, O.A. Martins-Filho); Universidade Federal de Minas Gerais, Belo Horizonte (J.G. Coelho-dos-Reis); Secretaria Municipal de Saúde, Belo Horizonte (J.A. Lemos); Secretaria do Estado de Saúde de Minas Gerais, Belo Horizonte (J.G.L. Ribeiro); Escola Nacional de Saúde Pública (FIOCRUZ-Rio), Rio de Janeiro, Brazil (L.A.B. Camacho); Instituto de Tecnologia em Imunobiológicos Bio-Manguinhos (FIOCRUZ-Rio),; Rio de Janeiro (M. de Lourdes de Sousa Maia, S.M. Barbosa de Lima, M. Simões, R. de Menezes Martins, A. Homma); Universidade Federal de Alfenas, Alfenas, Brazil (L.C.C. Malaquias); Universidade de Brasília, Brasília, Brazil (P.L. Tauil); Instituto Evandro Chagas, Ananindeua, Brazil (P.F.C. Vasconcelos); Secretaria de Vigilância em Saúde—Ministério da Saúde, Brasília (A.P.M. Romano, C.M. Domingues)

Main Article

Figure 5

Ascendant biomarker signatures before and after primary and secondary 17DD vaccination for YF. Overlaid biomarker signatures were assembled to identify changes in the 17DD-specific phenotypic and functional features observed over time in primary vaccination arm (A) and secondary vaccination arm (B). Color indicates time point before and after primary or secondary vaccination for each biomarker; dashed line indicates the global median >50th percentile. Boldface text indicates the 3 biomarkers

Figure 5. Ascendant biomarker signatures before and after primary and secondary 17DD vaccination for YF. Overlaid biomarker signatures were assembled to identify changes in the 17DD-specific phenotypic and functional features observed over time in primary vaccination arm (A) and secondary vaccination arm (B). Color indicates time point before and after primary or secondary vaccination for each biomarker; dashed line indicates the global median >50th percentile. Boldface text indicates the 3 biomarkers considered relevant universal attributes to monitor 17DD-YF–specific memory (EMCD4, EMCD8, IFNCD8). Participant subgroups indicate number of days or years since vaccination (in parentheses; d0 for those never vaccinated). IFN, interferon; IL, interleukin; TNF, tumor necrosis factor; YF, yellow fever.

Main Article

Page created: July 16, 2019
Page updated: July 16, 2019
Page reviewed: July 16, 2019
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