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Volume 25, Number 8—August 2019
Research Letter

Intrafamily Transmission of Monkeypox Virus, Central African Republic, 2018

Camille Besombes, Ella Gonofio, Xavier Konamna, Benjamin Selekon, Antoine Gessain, Nicolas Berthet, Jean-Claude Manuguerra, Arnaud Fontanet, and Emmanuel NakounéComments to Author 
Author affiliations: Institut Pasteur, Paris, France (C. Besombes, A. Gessain, N. Berthet, J.-C. Manuguerra, A. Fontanet); Institut Pasteur de Bangui, Bangui, Central African Republic (E. Gonofio, X. Konamna, B. Selekon, E. Nakouné); Centre National de la Recherche Scientifique, Paris (A. Gessain, N. Berthet); Unité Pasteur-CNAM Risques Infectieux et Emergents, Conservatoire National des Arts et Métiers, Paris (A. Fontanet)

Main Article

Table

Molecular and serologic evidence of index case and contacts with known and possible exposure to monkeypox virus, Central African Republic, 2018*

Patients Age, y/sex Symptom onset date Signs/ symptoms Animal contact Collection date Sample type
PCR‡
IgG§
Smallpox vaccine¶
Blood Pus† MPXV CPXV MPXV CPXV
Index case-patient
25/F
2018 Sep 8
Rash, lesions
Y
2018 Sep 27
Y
N

+




N
Contacts
Daughter 0.4/F 2018 Sep 20 Fever, rash, lesions N 2018 Sep 27 N Y + ND ND N
Daughter 4/F 2018 Sep 26 Fever, rash, lesions N 2018 Sep 27 Y N + N
Sister 16/F 2018 Oct 6 Rash, lesions N 2018 Oct 8 N Y + ND ND N
Sister 7/F 2018 Oct 9 Rash, lesions N 2018 Oct 11 Y N + N
SIL 33/F 2018 Oct 24 Rash, lesions N 2018 Oct 25 Y N + N
Mother 49/F NA None N 2018 Oct 5 Y N ND ND + + Y
Son 13/M NA None Y 2018 Oct 5 Y N ND ND N
Brother 49/M NA None Y 2018 Oct 25 Y N ND ND + Y
Brother 
of SIL 8/M NA None NK 2018 Oct 25 Y N ND ND + + N
Nephew 
of SIL 13/M NA None NK 2018 Oct 25 Y N ND ND N
HCW 34/M NA None N 2018 Oct 5 Y N ND ND + + N
HCW 45/F NA None N 2018 Oct 5 Y N ND ND + + Y
Social 
contact 22/F NA None NK 2018 Oct 25 Y N ND ND + N

*A total of 33 contacts were tested, 2 HCWs and 31 village contacts. CPXV, cowpox virus; HCW, healthcare worker; MPXV, monkeypox virus; NA, not applicable; ND, not done; NK, not known; SIL, sister-in-law; +, positive; –, negative.
†Samples obtained by HCWs after training on collecting swab samples.
‡Quantitative and conventional PCR were performed by using generic primers G2R-G and Congo Basin primers C3L (8).
§In-house tests were performed by using MPXV antigen isolated from local human cases and CPXV antigen related to Brighton Red strain.
¶History of smallpox vaccination was determined by verbal report and presence of scar.

Main Article

Page created: July 17, 2019
Page updated: July 17, 2019
Page reviewed: July 17, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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