Volume 25, Number 9—September 2019
Research
Effect of Pneumococcal Conjugate Vaccines on Pneumococcal Meningitis, England and Wales, July 1, 2000–June 30, 2016
Godwin Oligbu, Sarah Collins, Abdelmajid Djennad, Carmen L. Sheppard, Norman K. Fry, Nick J. Andrews, Ray Borrow, Mary E. Ramsay, and Shamez N. Ladhani
Table 2
Association between Streptococcus pneumoniae serotype and meningitis (vs. nonmeningitis) by serotype ranking, England and Wales, July 1, 2011–June 30, 1016*
| Serotype rank | Serotype | Total cases | Nonmeningitis cases, n = 20,800, no. (%) | Meningitis cases, n = 920, no. (%) | aOR (95% CI) | p value† |
|---|---|---|---|---|---|---|
| 1 | 8 | 3,285 | 3,184 (15.3) | 101 (11.0) | 0.69 (0.56–0.86) | <0.001 |
| 2 | 12F | 1,809 | 1,729 (8.3) | 80 (8.7) | 0.99 (0.78–1.27) | 0.961 |
| 3 | 22F | 1,725 | 1,640 (7.9) | 85 (9.2) | 1.39 (1.1–1.76) | 0.006 |
| 4 | 3 | 1,598 | 1,542 (7.4) | 56 (6.1) | 0.99 (0.74–1.31) | 0.924 |
| 5 | 7F | 1,542 | 1,482 (7.1) | 60 (6.5) | 0.73 (0.56–0.96) | 0.026 |
| 6 | 19A | 1,485 | 1,446 (7.0) | 39 (4.2) | 0.62 (0.45–0.86) | 0.005 |
| 7 | 15A | 1,024 | 986 (4.7) | 38 (4.1) | 1.09 (0.78–1.54) | 0.603 |
| 8 | 9N | 954 | 928 (4.5) | 26 (2.8) | 0.77 (0.51–1.15) | 0.2 |
| 9 | 33F | 827 | 774 (3.7) | 53 (5.8) | 1.34 (0.99–1.81) | 0.057 |
| 10 | 1 | 602 | 588 (2.8) | 14 (1.5) | 0.33 (0.19–0.56) | <0.001 |
| 11 | 10A | 566 | 511 (2.5) | 55 (6.0) | 2.06 (1.52–2.79) | <0.001 |
| 12 | 23A | 548 | 523 (2.5) | 25 (2.7) | 1.51 (1–2.29) | 0.052 |
| 13 | 24F | 548 | 528 (2.5) | 20 (2.2) | 0.73 (0.46–1.16) | 0.187 |
| 14 | 6C | 514 | 497 (2.4) | 17 (1.8) | 0.95 (0.58–1.57) | 0.852 |
| 15 | 11A | 512 | 498 (2.4) | 14 (1.5) | 0.71 (0.41–1.23) | 0.221 |
| 16 | 23B | 499 | 462 (2.2) | 37 (4.0) | 1.73 (1.21–2.48) | 0.003 |
| 17 | 15B/C | 453 | 416 (2.0) | 37 (4.0) | 1.31 (0.91–1.89) | 0.146 |
| 18 | 16F | 418 | 408 (2.0) | 10 (1.1) | 0.77 (0.41–1.45) | 0.415 |
| 19 | 35F | 371 | 349 (1.7) | 22 (2.4) | 1.47 (0.93–2.32) | 0.096 |
| 20 | 35B | 334 | 308 (1.5) | 26 (2.8) | 2.12 (1.38–3.25) | <0.001 |
| 21 | 31 | 282 | 273 (1.3) | 9 (1.0) | 1.14 (0.58–2.25) | 0.703 |
| 22 | 20 | 240 | 235 (1.1) | 5 (0.5) | 0.46 (0.19–1.12) | 0.086 |
| 23 | 38 | 239 | 229 (1.1) | 10 (1.1) | 0.79 (0.41–1.54) | 0.49 |
| 24 | 17F | 235 | 221 (1.1) | 14 (1.5) | 1.71 (0.98–2.98) | 0.058 |
| 25 | 19F | 183 | 171 (0.8) | 12 (1.3) | 1.24 (0.68–2.28) | 0.483 |
| 26 | 4 | 135 | 132 (0.6) | 3 (0.3) | 0.4 (0.13–1.28) | 0.123 |
| 27 | 14 | 94 | 93 (0.4) | 1 (0.1) | 0.26 (0.04–1.87) | 0.18 |
| 28 | 6A | 93 | 88 (0.4) | 5 (0.5) | 1.34 (0.52–3.45) | 0.538 |
| 29 | 6B | 90 | 88 (0.4) | 2 (0.2) | 0.54 (0.13–0.13) | 0.397 |
| 30 | 9V | 81 | 80 (0.4) | 1 (0.1) | 0.31 (0.04–2.25) | 0.245 |
| 31 | 23F | 60 | 57 (0.3) | 3 (0.3) | 1.24 (0.38–4.08) | 0.722 |
| 32 | 18C | 55 | 51 (0.2) | 4 (0.4) | 1.23 (0.43–3.52) | 0.701 |
| 33 |
21 |
51 |
47 (0.2) |
4 (0.4) |
0.8 (0.28–2.3) |
0.683 |
| *Values were adjusted for age and year of diagnosis. Only serotypes responsible for >50 cases of invasive pneumococcal disease were included. Serotypes of decreased odds (decreased aORs with significant p values) are indicated in light gray, and serotypes of increased odds (increased aORs and significant p values) are indicated in dark gray. aOR, adjusted odds ratio. †Because of multiple comparisons, a p value of <0.01 was considered significant. | ||||||
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