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Volume 25, Number 9—September 2019
Research

Genetic Characterization and Enhanced Surveillance of Ceftriaxone-Resistant Neisseria gonorrhoeae Strain, Alberta, Canada, 2018

Byron M. BerengerComments to Author , Walter Demczuk, Jennifer Gratrix, Kanti Pabbaraju, Petra Smyczek, and Irene Martin
Author affiliations: University of Calgary, Calgary, Alberta, Canada (B. Berenger); Alberta Public Laboratories, Calgary (B. Berenger, K. Pabbaraju); Public Health Agency of Canada, Winnipeg, Manitoba, Canada (W. Demczuk, I. Martin); Alberta Health Services, Edmonton, Alberta (J. Gratrix, P. Smyczek)

Main Article

Table 1

Phenotypic and genetic antibiotic susceptibility testing for ceftriaxone-resistant Neisseria gonorrhoeae isolate, Alberta, Canada, 2018

Antimicrobial drug Etest MIC, μg/mL Agar dilution, μg/mL Interpretation Genetic markers/mutations identified in genome: result
Ceftriaxone
 0.5–1
 0.5
 R
 penA: mosaic 60.001, A311V, T483S; mtrR promoter: –35A deletion; mtrR: wild types for A39 and G45; porB: G120K, A121D; porB structure: porB1b; ponA: L421P
Cefixime
 2
 2
 R
Penicillin
 4
 2
 R
Ertapenem
 0.064
 0.125
 NS
Azithromycin
 0.5–1
 0.25
 S
 23S rRNA A2059G and C2611T: absent; ermB: negative; ermC: negative; mtrR promoter: –35A deletion; mtrR: wild types for A39 and G45
Ciprofloxacin
 >32
 32
 R
 gyrA: S91F and D95A; parC: D86, S87R, and wild type S88
Tetracycline
 1
 2
 R†
 rpsJ: rpsJ_3 (V57M); tetM: negative; mtrR promoter: –35A deletion; mtrR: wild types for A39 and G45
Gentamicin
 ND
 8
 S
 Genetic resistance determinants not determined
Spectinomycin
 ND
 16
 S
Moxifloxacin 4 ND NA

*Interpretations based on agar dilution. NA, breakpoint not available; ND, not done; NS, nonsusceptible; R, resistant; S, susceptible.
†Tetracycline resistance would be intermediate on the basis of Etest MIC.

Main Article

Page created: August 21, 2019
Page updated: August 21, 2019
Page reviewed: August 21, 2019
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