TY - JOUR AU - Bellanger, Anne-Pauline AU - Berceanu, Ana AU - Scherer, Emeline AU - Desbrosses, Yohan AU - Daguindau, Etienne AU - Rocchi, Steffi AU - Millon, Laurence T1 - Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients T2 - Emerging Infectious Disease journal PY - 2019 VL - 25 IS - 9 SP - 1778 SN - 1080-6059 AB - We present 2 fatal cases of invasive fungal disease with isavuconazole treatment failure in immunocompromised patients: one with a TR34-L98H azole–resistant Aspergillus fumigatus isolate and the other a Rhizomucor–A. fumigatus co-infection. Such patients probably require surveillance by galactomannan antigen detection and quantitative PCRs for A. fumigatus and Mucorales fungi. KW - aspergillosis KW - fungal co-infection KW - invasive fungal disease KW - isavuconazole KW - treatment failure KW - mucormycosis KW - qPCR KW - CT KW - graft-versus-host disease KW - Aspergillus fumigatus KW - Rhizomucor KW - France KW - antimicrobial resistance KW - fungi KW - acute myeloid leukemia KW - hematopoietic stem-cell transplantation KW - galactomannan antigen KW - immunocompromised patients KW - death KW - quantitative PCR KW - computed tomography DO - 10.3201/eid2509.190598 UR - https://wwwnc.cdc.gov/eid/article/25/9/19-0598_article ER - End of Reference