TY - JOUR AU - Bett, Cyrus AU - Andrews, Omozusi AU - Asher, David AU - Pilant, Teresa AU - Keire, David AU - Gregori, Luisa T1 - Eliminating Spiked Bovine Spongiform Encephalopathy Agent Activity from Heparin T2 - Emerging Infectious Disease journal PY - 2020 VL - 26 IS - 10 SP - 2478 SN - 1080-6059 AB - US manufacturers, concerned about bovine spongiform encephalopathy (BSE), ceased marketing bovine heparin in the 1990s. Recent short supplies of safe porcine heparin suggest that reintroducing bovine heparin might benefit public health. We purified heparin from crude bovine extract spiked with BSE agent, removing substantial infectivity and abnormal prion proteins (PrPTSE). KW - bovine spongiform encephalopathy KW - bovine heparin KW - porcine heparin KW - heparin KW - prions KW - prion protein DO - 10.3201/eid2610.200142 UR - https://wwwnc.cdc.gov/eid/article/26/10/20-0142_article ER - End of Reference