Volume 26, Number 10—October 2020
Research
Association between Shiga Toxin–Producing Escherichia coli O157:H7 stx Gene Subtype and Disease Severity, England, 2009–2019
Lisa Byrne
, Natalie Adams, and Claire Jenkins
, Natalie Adams, and Claire Jenkins
Table 1
Disease severity of 3,241 clinical cases of Shiga toxin–producing Escherichia coli O157:H7 Stx subtype infection, by patient age, sex, and isolate Stx subtype, England, 2009–2019*
| Variable | All cases, no. (%) | Mild illness, no. (%)† | Severe illness, no. (%)‡ | HUS, no. (%) |
|---|---|---|---|---|
| All O157s |
3,241 |
1,352 (41.7) |
1,889 (58.3) |
86 (2.7) |
| Age group | ||||
| Child | 1,185 (36.5) | 586 (49.5) | 599 (50.5) | 66 (5.6) |
| Adult |
2,056 (63.5) |
766 (37.3) |
1,290 (62.7) |
20 (1.0) |
| Sex | ||||
| F | 1,841 (56.8) | 742 (40.3) | 1,099 (59.7) | 54 (2.9) |
| M |
1,400 (43.2) |
610 (43.6) |
790 (56.4) |
32 (2.3) |
| Stx subtype | ||||
| stx2c stx1a | 903 (28) | 286 (31.7) | 617 (68.3) | 0 |
| stx2c | 675 (20.9) | 535 (79.3) | 140 (20.7) | 2 (0.3) |
| stx2a | 686 (21.3) | 254 (37) | 432 (63) | 27 (3.9) |
| stx2a stx2c | 829 (25.7) | 240 (29) | 589 (71) | 50 (6.0) |
| stx1a | 32 (1) | 13 (40.6) | 19 (59.4) | 0 |
| stx2a stx1a | 51 (1.6) | 9 (17.6) | 42 (82.4) | 0 |
| stx2a stx2c stx1a | 49 (1.5) | 9 (18.4) | 40 (81.6) | 0 |
| No Stx subtype§ | 16 (0.5) | 6 (0.4) | 10 (0.5) | 0 |
*HUS, hemolytic uremic syndrome.
†Asymptomatic or nonbloody diarrhea.
‡Bloody diarrhea, HUS, or death.
§Isolates underwent whole-genome sequencing, but Stx subtype was not available.
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