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Volume 26, Number 10—October 2020
Research Letter

Disappearance of SARS-CoV-2 Antibodies in Infants Born to Women with COVID-19, Wuhan, China

Jinzhi Gao1, Wei Li1, Xiaolin Hu, Ying Wei, Jianli Wu, Xiaoping Luo, Suhua ChenComments to Author , and Ling ChenComments to Author 
Author affiliations: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Main Article

Table

Sequential severe acute respiratory syndrome coronavirus 2–specific antibodies assay in 24 infants born to mothers with PCR-confirmed coronavirus disease, Wuhan, China, January 19–April 12, 2020*

Case no.
 GA, wk+d
At symptom onset At birth
IgM/IgG titers, AU/mL, by age of infant
0 d 7 d 14 d 28 d 45 d 60 d 75 d
1
 Mother 7.5/116.9* 33+4
 36+3
Infant
0.8/0.3
2
 Mother 4.4/118.3 38+5
 38+5
Infant
0.5/2.5
3
 Mother 5.0/83.3 37+5
 38+2
Infant
0.4/0.2
4
 Mother 14.5/100.8 39+1
 39+5
Infant
0.3/0.3
5
 Mother 34
 35+2
Infant
0.7/2.8
 0.4/3.5
 0.3/0.9
6
 Mother 7.0/93.0 39+3
 40
Infant
0.4/0.3
7
 Mother 51.1/94.6 39+4
 41+2
Infant
0.3/0.9
8
 Mother 67.0/92.6 37+4
 38+4
Infant
0.3/0.1
9
 Mother 17.8/104.3 38+2
 39+5
Infant
0.4/8.2
10
 Mother 15.3/95.4 9.9/108.7 38+1
 39+5
Infant
2.2/32.7
0.7/19.5
11
 Mother 11.3/112.5 5.3/105.6 35+5
 38+2
Infant
3.6/166.0
 5.3/120.8
 1.0/36.2
0.4/16.2
12
 Mother +/+† 37.9/94.6 29+4
 31
Infant
5.7/142.0
 2.6/113.9
 1.8/75.3
 0.3/22.0
0.4/11.3
13
 Mother +/+ 34+3
 38
Infant
 3.5/134.1
 2.4/125.0
 2.8/119.0
 0.7/24.6
14
 Mother 7.0/61.1 1.9/59.5 34+6
 39
Infant
 2.2/78.4
 1.5/76.9
 3.0/80.9
 0.8/28.6
0.5/13.0
15
 Mother 0.7/58.9 NA
 37+2
Infant
 8.5/174.5
7.8/122.7
16
 Mother +/+ NA
 38+3
Infant
 0.7/101.0
17
 Mother +/+ 1.5/104.2 NA
 38+3
Infant
 1.2/110.4
 10.4/108.9
2.1/68.2
18
 Mother –/+ 4.8/54.5 NA
 39+5
Infant
 6.6/96.2
 11.3/86.0
 11.9/88.3
 2.5/60.9
19
 Mother 2,581.6/281 40.2/89.8 13.9/99.6 6.9/94.2 32+1
 38
Infant
 184.3/147.2
 42.6/161.6
 21.2/83.8
 5.5/79.2
 1.6/57.0
0.3/25.9
20
 Mother 6.9/82.8 6.0/81.3 31+1
 39+5
Infant
25.7/68.8
3.0/58.4
 0.4/47.4
21
 Mother +/+ 5.1/139.0 30+3
 38
Infant
 26.0/145.8
 41.8/120.1
 42.9/110.1
 38.0/89.5
14.2/105.3
22
 Mother +/+ 30
 30
Infant
 22.8/116.5
 11.8/104.4
 8.7/99.8
 1.9/75.2
23
 Mother +/+ 10.5/101.6 4.3/115.6 32+1
 32+1
Infant
 15.8/222.1
 33.8/182.5
 9.0/88.2
 6.1/82.5
0.5/31.1
24 Mother +/+ –/+ 8.0/83.9 NA NA
Infant 30.1/106.0 29.5/84.6 31.5/94.9 9.7/73.1

*Bold text indicates titer >10 AU/mL (i.e., above cutoff). GA, gestational age; NA, not available; –, negative; +, positive.
†Some mothers delivered in other hospitals, and antibody testing was conducted using other qualitative antibody-detection kits.

Main Article

1These first authors contributed equally to this article.

Page created: June 23, 2020
Page updated: September 17, 2020
Page reviewed: September 17, 2020
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